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Roles of sex steroid receptors and cell cycle regulation in pathogenesis of pelvic organ prolapse
DC Field | Value | Language |
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dc.contributor.author | 배상욱 | - |
dc.date.accessioned | 2015-06-10T12:00:40Z | - |
dc.date.available | 2015-06-10T12:00:40Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 1040-872X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/109027 | - |
dc.description.abstract | PURPOSE OF REVIEW: The cause of pelvic organ prolapse is multifactorial and many inciting, promoting and decompensating factors play a role in developing pelvic organ prolapse. Various clinical parameters have been studied quite extensively, but estrogen and collagen metabolism and cell proliferation and apoptosis have not been widely evaluated. This review focuses on assessing the roles of estrogen and its receptor, relationship with collagen metabolism and cell proliferation and cell apoptosis in development and progression of pelvic organ prolapse. RECENT FINDINGS: Differential expressions of sex steroid receptors in various suspensory ligaments of prolapsed uteri have been studied. How different subtypes of estrogen receptor play a role in inducing and aggravating pelvic organ prolapse has yet to be defined. The role of estrogen in collagen metabolism and cell proliferation related to development of pelvic organ prolapse is still under study. Studies on the proliferation of fibroblasts in ligaments of pelvic organ prolapse have yielded conflicting results. SUMMARY: There is still a need for additional research on precise roles of sex steroids, their receptors and cell cycle regulatory proteins and cell proliferation in pathogenesis of pelvic organ prolapse. Some of them could be the cause of pelvic organ prolapse and some of them the direct result of tissue trauma in pelvic organ prolapse. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 551~554 | - |
dc.relation.isPartOf | CURRENT OPINION IN OBSTETRICS & GYNECOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Apoptosis/physiology | - |
dc.subject.MESH | Cell Division/physiology | - |
dc.subject.MESH | Estrogen Receptor alpha/metabolism | - |
dc.subject.MESH | Estrogen Receptor beta/metabolism | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Ovary/metabolism* | - |
dc.subject.MESH | Receptors, Steroid/metabolism* | - |
dc.subject.MESH | Uterine Prolapse/metabolism* | - |
dc.title | Roles of sex steroid receptors and cell cycle regulation in pathogenesis of pelvic organ prolapse | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Obstetrics & Gynecology (산부인과학) | - |
dc.contributor.googleauthor | Da Jung Chung | - |
dc.contributor.googleauthor | Sang Wook Bai | - |
dc.identifier.doi | 10.1097/01.gco.0000242959.63362.1e | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01793 | - |
dc.relation.journalcode | J00676 | - |
dc.identifier.eissn | 1473-656X | - |
dc.identifier.pmid | 16932051 | - |
dc.identifier.url | http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00001703-200610000-00013&LSLINK=80&D=ovft | - |
dc.subject.keyword | cell proliferation and apoptosis, pathogenesis of POP, sex steroid receptors, sex steroids | - |
dc.contributor.alternativeName | Bai, Sang Wook | - |
dc.contributor.affiliatedAuthor | Bai, Sang Wook | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 18 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 551 | - |
dc.citation.endPage | 554 | - |
dc.identifier.bibliographicCitation | CURRENT OPINION IN OBSTETRICS & GYNECOLOGY, Vol.18(5) : 551-554, 2006 | - |
dc.identifier.rimsid | 53722 | - |
dc.type.rims | ART | - |
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