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Indocyanine Green Angiographic Features of Myopic Subfoveal Choroidal Neovascularization as a Prognostic Factor after Photodynamic Therapy

 Suk Ho Byeon  ;  Oh Woong Kwon  ;  Sung Chul Lee  ;  Sung Soo Kim  ;  Hyoung Jun Koh 
 Korean Journal of Ophthalmology, Vol.20(1) : 18-25, 2006 
Journal Title
 Korean Journal of Ophthalmology 
Issue Date
Adult ; Aged ; Choroidal Neovascularization/complications ; Choroidal Neovascularization/drug therapy ; Choroidal Neovascularization/pathology* ; Coloring Agents* ; Female ; Fluorescein Angiography/methods* ; Follow-Up Studies ; Fovea Centralis/pathology* ; Fundus Oculi ; Humans ; Indocyanine Green* ; Male ; Middle Aged ; Myopia/complications* ; Myopia/pathology ; Photochemotherapy* ; Prognosis ; Retrospective Studies ; Visual Acuity
Choroidal neovascularization (CNV) ; Degenerative myopia ; Dark rim ; Indocyanine green angiography (ICG) ; Myopia
Purpose: To determine the influence of clinical features and Indocyanine green (ICG) angiographic features on the visual outcome of patients with myopic sub-foveal choroidal neovascularization (CNV) who received photodynamic therapy (PDT). Methods: Thirty-six consecutive patients (39 eyes) with myopic CNV who were followed up for more than one year after PDT were enrolled in this study. Clinical features included age, gender, refractive error, great linear dimension, and subretinal hemorrhage. ICG features included the lesion size, lacquer cracks, hypofluorescence surrounding the CNV (dark rim), peripapillary atrophy size, and visible prominent choroidal veins under the macula. Linear regression analysis was performed using the change in visual acuity (ΔlogMAR) as the dependent variable and the above factors as independent variables. Results: At one-year follow-up after PDT, a younger age (p=0.002) and the presence of a dark rim (p=0.002) were significantly correlated with an improvement of visual acuity (decrement in logMAR) after PDT. Other factors had no significant influence on changes in visual acuity. Conclusions: Younger patients and patients with a dark rim on ICG angiography had a higher chance of visual improvement after PDT in myopic CNV.
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1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Koh, Hyoung Jun(고형준) ORCID logo https://orcid.org/0000-0002-5932-8516
Kwon, Oh Woong(권오웅)
Kim, Sung Soo(김성수) ORCID logo https://orcid.org/0000-0002-0574-7993
Byeon, Suk Ho(변석호) ORCID logo https://orcid.org/0000-0001-8101-0830
Lee, Sung Chul(이성철) ORCID logo https://orcid.org/0000-0001-9438-2385
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