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Effect of subthalamic nucleus lesions in a 6-hydroxydopamine–induced rat parkinsonian model: behavioral and biochemical studies

Authors
 Yong Sup Hwang  ;  Insop Shim  ;  Bom Bee Lee  ;  Jin Woo Chang 
Citation
 JOURNAL OF NEUROSURGERY, Vol.105(2) : 284-287, 2006 
Journal Title
JOURNAL OF NEUROSURGERY
ISSN
 0022-3085 
Issue Date
2006
MeSH
3,4-Dihydroxyphenylacetic Acid/metabolism ; Animals ; Corpus Striatum/pathology ; Corpus Striatum/physiopathology ; Dominance, Cerebral/physiology ; Dopamine/metabolism* ; Globus Pallidus/pathology ; Globus Pallidus/physiopathology ; Kainic Acid ; Male ; Motor Activity/physiology* ; Motor Skills/physiology* ; Neural Pathways/pathology ; Neural Pathways/physiopathology ; Oxidopamine ; Parkinsonian Disorders/pathology ; Parkinsonian Disorders/physiopathology* ; Rats ; Rats, Sprague-Dawley ; Stereotyped Behavior/physiology* ; Subthalamic Nucleus/pathology ; Subthalamic Nucleus/physiopathology*
Abstract
OBJECT: The purpose of this study was to determine whether subthalamic nucleus (STN) ablation caused by kainic acid can restore dopaminergic neurotransmission and improve motor deficits in a 6-hydroxydopamine (6-OHDA)-induced hemiparkinsonian model.
METHODS: The authors investigated behavioral changes in rats displaying parkinsonian symptoms (6-OHDA-lesioned rats) after an STN lesion was created using kainic acid. They also measured levels of dopamine and its metabolites following tissue dissection. The results of this study showed that STN ablation led to behavioral improvement in parkinsonian motor deficits. Increased levels of dopamine were also observed in the striatum and globus pallidus externus (GPE).
CONCLUSIONS: The results indicate that creation of an STN lesion in this hemiparkinsonian rat model may counteract some of the neurochemical changes within the striatum and GPE caused by the 6-OHDA, and influence striatal dopaminergic metabolism.
Full Text
http://thejns.org/doi/abs/10.3171/jns.2006.105.2.284
DOI
10.3171/jns.2006.105.2.284
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Chang, Jin Woo(장진우) ORCID logo https://orcid.org/0000-0002-2717-0101
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/108970
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