Cited 6 times in
Effect of subthalamic nucleus lesions in a 6-hydroxydopamine–induced rat parkinsonian model: behavioral and biochemical studies
DC Field | Value | Language |
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dc.contributor.author | 장진우 | - |
dc.date.accessioned | 2015-06-10T11:58:50Z | - |
dc.date.available | 2015-06-10T11:58:50Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0022-3085 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/108970 | - |
dc.description.abstract | OBJECT: The purpose of this study was to determine whether subthalamic nucleus (STN) ablation caused by kainic acid can restore dopaminergic neurotransmission and improve motor deficits in a 6-hydroxydopamine (6-OHDA)-induced hemiparkinsonian model. METHODS: The authors investigated behavioral changes in rats displaying parkinsonian symptoms (6-OHDA-lesioned rats) after an STN lesion was created using kainic acid. They also measured levels of dopamine and its metabolites following tissue dissection. The results of this study showed that STN ablation led to behavioral improvement in parkinsonian motor deficits. Increased levels of dopamine were also observed in the striatum and globus pallidus externus (GPE). CONCLUSIONS: The results indicate that creation of an STN lesion in this hemiparkinsonian rat model may counteract some of the neurochemical changes within the striatum and GPE caused by the 6-OHDA, and influence striatal dopaminergic metabolism. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 284~287 | - |
dc.relation.isPartOf | JOURNAL OF NEUROSURGERY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | 3,4-Dihydroxyphenylacetic Acid/metabolism | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Corpus Striatum/pathology | - |
dc.subject.MESH | Corpus Striatum/physiopathology | - |
dc.subject.MESH | Dominance, Cerebral/physiology | - |
dc.subject.MESH | Dopamine/metabolism* | - |
dc.subject.MESH | Globus Pallidus/pathology | - |
dc.subject.MESH | Globus Pallidus/physiopathology | - |
dc.subject.MESH | Kainic Acid | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Motor Activity/physiology* | - |
dc.subject.MESH | Motor Skills/physiology* | - |
dc.subject.MESH | Neural Pathways/pathology | - |
dc.subject.MESH | Neural Pathways/physiopathology | - |
dc.subject.MESH | Oxidopamine | - |
dc.subject.MESH | Parkinsonian Disorders/pathology | - |
dc.subject.MESH | Parkinsonian Disorders/physiopathology* | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Stereotyped Behavior/physiology* | - |
dc.subject.MESH | Subthalamic Nucleus/pathology | - |
dc.subject.MESH | Subthalamic Nucleus/physiopathology* | - |
dc.title | Effect of subthalamic nucleus lesions in a 6-hydroxydopamine–induced rat parkinsonian model: behavioral and biochemical studies | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurosurgery (신경외과학) | - |
dc.contributor.googleauthor | Yong Sup Hwang | - |
dc.contributor.googleauthor | Insop Shim | - |
dc.contributor.googleauthor | Bom Bee Lee | - |
dc.contributor.googleauthor | Jin Woo Chang | - |
dc.identifier.doi | 10.3171/jns.2006.105.2.284 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03484 | - |
dc.relation.journalcode | J01636 | - |
dc.identifier.eissn | 1933-0693 | - |
dc.identifier.pmid | 17219835 | - |
dc.identifier.url | http://thejns.org/doi/abs/10.3171/jns.2006.105.2.284 | - |
dc.contributor.alternativeName | Chang, Jin Woo | - |
dc.contributor.affiliatedAuthor | Chang, Jin Woo | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 105 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 284 | - |
dc.citation.endPage | 287 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NEUROSURGERY, Vol.105(2) : 284-287, 2006 | - |
dc.identifier.rimsid | 53678 | - |
dc.type.rims | ART | - |
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