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Effect of subthalamic nucleus lesions in a 6-hydroxydopamine–induced rat parkinsonian model: behavioral and biochemical studies

DC Field Value Language
dc.contributor.author장진우-
dc.date.accessioned2015-06-10T11:58:50Z-
dc.date.available2015-06-10T11:58:50Z-
dc.date.issued2006-
dc.identifier.issn0022-3085-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/108970-
dc.description.abstractOBJECT: The purpose of this study was to determine whether subthalamic nucleus (STN) ablation caused by kainic acid can restore dopaminergic neurotransmission and improve motor deficits in a 6-hydroxydopamine (6-OHDA)-induced hemiparkinsonian model. METHODS: The authors investigated behavioral changes in rats displaying parkinsonian symptoms (6-OHDA-lesioned rats) after an STN lesion was created using kainic acid. They also measured levels of dopamine and its metabolites following tissue dissection. The results of this study showed that STN ablation led to behavioral improvement in parkinsonian motor deficits. Increased levels of dopamine were also observed in the striatum and globus pallidus externus (GPE). CONCLUSIONS: The results indicate that creation of an STN lesion in this hemiparkinsonian rat model may counteract some of the neurochemical changes within the striatum and GPE caused by the 6-OHDA, and influence striatal dopaminergic metabolism.-
dc.description.statementOfResponsibilityopen-
dc.format.extent284~287-
dc.relation.isPartOfJOURNAL OF NEUROSURGERY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESH3,4-Dihydroxyphenylacetic Acid/metabolism-
dc.subject.MESHAnimals-
dc.subject.MESHCorpus Striatum/pathology-
dc.subject.MESHCorpus Striatum/physiopathology-
dc.subject.MESHDominance, Cerebral/physiology-
dc.subject.MESHDopamine/metabolism*-
dc.subject.MESHGlobus Pallidus/pathology-
dc.subject.MESHGlobus Pallidus/physiopathology-
dc.subject.MESHKainic Acid-
dc.subject.MESHMale-
dc.subject.MESHMotor Activity/physiology*-
dc.subject.MESHMotor Skills/physiology*-
dc.subject.MESHNeural Pathways/pathology-
dc.subject.MESHNeural Pathways/physiopathology-
dc.subject.MESHOxidopamine-
dc.subject.MESHParkinsonian Disorders/pathology-
dc.subject.MESHParkinsonian Disorders/physiopathology*-
dc.subject.MESHRats-
dc.subject.MESHRats, Sprague-Dawley-
dc.subject.MESHStereotyped Behavior/physiology*-
dc.subject.MESHSubthalamic Nucleus/pathology-
dc.subject.MESHSubthalamic Nucleus/physiopathology*-
dc.titleEffect of subthalamic nucleus lesions in a 6-hydroxydopamine–induced rat parkinsonian model: behavioral and biochemical studies-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurosurgery (신경외과학)-
dc.contributor.googleauthorYong Sup Hwang-
dc.contributor.googleauthorInsop Shim-
dc.contributor.googleauthorBom Bee Lee-
dc.contributor.googleauthorJin Woo Chang-
dc.identifier.doi10.3171/jns.2006.105.2.284-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03484-
dc.relation.journalcodeJ01636-
dc.identifier.eissn1933-0693-
dc.identifier.pmid17219835-
dc.identifier.urlhttp://thejns.org/doi/abs/10.3171/jns.2006.105.2.284-
dc.contributor.alternativeNameChang, Jin Woo-
dc.contributor.affiliatedAuthorChang, Jin Woo-
dc.rights.accessRightsnot free-
dc.citation.volume105-
dc.citation.number2-
dc.citation.startPage284-
dc.citation.endPage287-
dc.identifier.bibliographicCitationJOURNAL OF NEUROSURGERY, Vol.105(2) : 284-287, 2006-
dc.identifier.rimsid53678-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers

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