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Dopamine neurons derived from embryonic stem cells efficiently induce behavioral recovery in a Parkinsonian rat model

Authors
 Yoon Hee Cho  ;  Dae-Sung Kim  ;  Peter Geon Kim  ;  Yong Sup Hwang  ;  Myung Soo Cho  ;  Shin Yong Moon  ;  Dong-Wook Kim  ;  Jin Woo Chang 
Citation
 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.341(1) : 6-12, 2006 
Journal Title
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
ISSN
 0006-291X 
Issue Date
2006
MeSH
Animals ; Cell Differentiation ; Disease Models, Animal ; Dopamine/metabolism* ; Male ; Mental Disorders/diagnosis ; Mental Disorders/prevention & control* ; Neurons/metabolism ; Neurons/pathology* ; Neurons/transplantation* ; Parkinsonian Disorders/complications ; Parkinsonian Disorders/metabolism ; Parkinsonian Disorders/pathology ; Parkinsonian Disorders/physiopathology* ; Rats ; Rats, Sprague-Dawley ; Recovery of Function ; Stem Cell Transplantation/methods* ; Stem Cells/metabolism ; Stem Cells/pathology* ; Treatment Outcome
Abstract
To test the in vivo effect of a high yield of dopaminergic (DA) neurons (90% of total neurons) which had been generated from a genetically modified mouse embryonic stem cell line, N2, the cells were transplanted into a rat model of Parkinson’s disease (PD). The PD animals grafted with N2-derived cells showed significant behavior improvements compared with sham controls from 2 weeks posttransplantation, whereas animals with naïve D3-derived cells (∼28% DA neurons of total neurons) showed only a modest recovery. Furthermore, hyperactivity observed in the subthalamic nucleus, pedunculopontine nucleus, and substantia nigra pars reticulata of PD rat models was dramatically reduced by the grafting of N2-derived cells. The number of DA neurons in the striatum which originated from N2 grafting was much higher compared to that from D3 grafting, and the neurons efficiently released DA in the brain, showing a good correlation with behavioral recovery.
Full Text
http://www.sciencedirect.com/science/article/pii/S0006291X05028901
DOI
10.1016/j.bbrc.2005.12.140
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Wook(김동욱) ORCID logo https://orcid.org/0000-0002-5025-1532
Chang, Jin Woo(장진우) ORCID logo https://orcid.org/0000-0002-2717-0101
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/108927
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