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Cited 19 times in

Dopamine neurons derived from embryonic stem cells efficiently induce behavioral recovery in a Parkinsonian rat model

DC Field Value Language
dc.contributor.author김동욱-
dc.contributor.author장진우-
dc.date.accessioned2015-06-10T11:57:27Z-
dc.date.available2015-06-10T11:57:27Z-
dc.date.issued2006-
dc.identifier.issn0006-291X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/108927-
dc.description.abstractTo test the in vivo effect of a high yield of dopaminergic (DA) neurons (90% of total neurons) which had been generated from a genetically modified mouse embryonic stem cell line, N2, the cells were transplanted into a rat model of Parkinson’s disease (PD). The PD animals grafted with N2-derived cells showed significant behavior improvements compared with sham controls from 2 weeks posttransplantation, whereas animals with naïve D3-derived cells (∼28% DA neurons of total neurons) showed only a modest recovery. Furthermore, hyperactivity observed in the subthalamic nucleus, pedunculopontine nucleus, and substantia nigra pars reticulata of PD rat models was dramatically reduced by the grafting of N2-derived cells. The number of DA neurons in the striatum which originated from N2 grafting was much higher compared to that from D3 grafting, and the neurons efficiently released DA in the brain, showing a good correlation with behavioral recovery.-
dc.description.statementOfResponsibilityopen-
dc.format.extent6~12-
dc.relation.isPartOfBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHCell Differentiation-
dc.subject.MESHDisease Models, Animal-
dc.subject.MESHDopamine/metabolism*-
dc.subject.MESHMale-
dc.subject.MESHMental Disorders/diagnosis-
dc.subject.MESHMental Disorders/prevention & control*-
dc.subject.MESHNeurons/metabolism-
dc.subject.MESHNeurons/pathology*-
dc.subject.MESHNeurons/transplantation*-
dc.subject.MESHParkinsonian Disorders/complications-
dc.subject.MESHParkinsonian Disorders/metabolism-
dc.subject.MESHParkinsonian Disorders/pathology-
dc.subject.MESHParkinsonian Disorders/physiopathology*-
dc.subject.MESHRats-
dc.subject.MESHRats, Sprague-Dawley-
dc.subject.MESHRecovery of Function-
dc.subject.MESHStem Cell Transplantation/methods*-
dc.subject.MESHStem Cells/metabolism-
dc.subject.MESHStem Cells/pathology*-
dc.subject.MESHTreatment Outcome-
dc.titleDopamine neurons derived from embryonic stem cells efficiently induce behavioral recovery in a Parkinsonian rat model-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Physiology (생리학)-
dc.contributor.googleauthorYoon Hee Cho-
dc.contributor.googleauthorDae-Sung Kim-
dc.contributor.googleauthorPeter Geon Kim-
dc.contributor.googleauthorYong Sup Hwang-
dc.contributor.googleauthorMyung Soo Cho-
dc.contributor.googleauthorShin Yong Moon-
dc.contributor.googleauthorDong-Wook Kim-
dc.contributor.googleauthorJin Woo Chang-
dc.identifier.doi10.1016/j.bbrc.2005.12.140-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03484-
dc.contributor.localIdA00406-
dc.relation.journalcodeJ00281-
dc.identifier.eissn1090-2104-
dc.identifier.pmid16412382-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0006291X05028901-
dc.contributor.alternativeNameKim, Dong Wook-
dc.contributor.alternativeNameChang, Jin Woo-
dc.contributor.affiliatedAuthorChang, Jin Woo-
dc.contributor.affiliatedAuthorKim, Dong Wook-
dc.rights.accessRightsnot free-
dc.citation.volume341-
dc.citation.number1-
dc.citation.startPage6-
dc.citation.endPage12-
dc.identifier.bibliographicCitationBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.341(1) : 6-12, 2006-
dc.identifier.rimsid50346-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers

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