Cited 19 times in
Dopamine neurons derived from embryonic stem cells efficiently induce behavioral recovery in a Parkinsonian rat model
DC Field | Value | Language |
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dc.contributor.author | 김동욱 | - |
dc.contributor.author | 장진우 | - |
dc.date.accessioned | 2015-06-10T11:57:27Z | - |
dc.date.available | 2015-06-10T11:57:27Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/108927 | - |
dc.description.abstract | To test the in vivo effect of a high yield of dopaminergic (DA) neurons (90% of total neurons) which had been generated from a genetically modified mouse embryonic stem cell line, N2, the cells were transplanted into a rat model of Parkinson’s disease (PD). The PD animals grafted with N2-derived cells showed significant behavior improvements compared with sham controls from 2 weeks posttransplantation, whereas animals with naïve D3-derived cells (∼28% DA neurons of total neurons) showed only a modest recovery. Furthermore, hyperactivity observed in the subthalamic nucleus, pedunculopontine nucleus, and substantia nigra pars reticulata of PD rat models was dramatically reduced by the grafting of N2-derived cells. The number of DA neurons in the striatum which originated from N2 grafting was much higher compared to that from D3 grafting, and the neurons efficiently released DA in the brain, showing a good correlation with behavioral recovery. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 6~12 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cell Differentiation | - |
dc.subject.MESH | Disease Models, Animal | - |
dc.subject.MESH | Dopamine/metabolism* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mental Disorders/diagnosis | - |
dc.subject.MESH | Mental Disorders/prevention & control* | - |
dc.subject.MESH | Neurons/metabolism | - |
dc.subject.MESH | Neurons/pathology* | - |
dc.subject.MESH | Neurons/transplantation* | - |
dc.subject.MESH | Parkinsonian Disorders/complications | - |
dc.subject.MESH | Parkinsonian Disorders/metabolism | - |
dc.subject.MESH | Parkinsonian Disorders/pathology | - |
dc.subject.MESH | Parkinsonian Disorders/physiopathology* | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Recovery of Function | - |
dc.subject.MESH | Stem Cell Transplantation/methods* | - |
dc.subject.MESH | Stem Cells/metabolism | - |
dc.subject.MESH | Stem Cells/pathology* | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Dopamine neurons derived from embryonic stem cells efficiently induce behavioral recovery in a Parkinsonian rat model | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Physiology (생리학) | - |
dc.contributor.googleauthor | Yoon Hee Cho | - |
dc.contributor.googleauthor | Dae-Sung Kim | - |
dc.contributor.googleauthor | Peter Geon Kim | - |
dc.contributor.googleauthor | Yong Sup Hwang | - |
dc.contributor.googleauthor | Myung Soo Cho | - |
dc.contributor.googleauthor | Shin Yong Moon | - |
dc.contributor.googleauthor | Dong-Wook Kim | - |
dc.contributor.googleauthor | Jin Woo Chang | - |
dc.identifier.doi | 10.1016/j.bbrc.2005.12.140 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03484 | - |
dc.contributor.localId | A00406 | - |
dc.relation.journalcode | J00281 | - |
dc.identifier.eissn | 1090-2104 | - |
dc.identifier.pmid | 16412382 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0006291X05028901 | - |
dc.contributor.alternativeName | Kim, Dong Wook | - |
dc.contributor.alternativeName | Chang, Jin Woo | - |
dc.contributor.affiliatedAuthor | Chang, Jin Woo | - |
dc.contributor.affiliatedAuthor | Kim, Dong Wook | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 341 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 6 | - |
dc.citation.endPage | 12 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.341(1) : 6-12, 2006 | - |
dc.identifier.rimsid | 50346 | - |
dc.type.rims | ART | - |
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