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Effects of milrinone on blood flow of the Y-graft composed with the radial and the internal thoracic artery in patients with coronary artery disease

Authors
 Sungwon Na  ;  Young Jun Oh  ;  Yon Hee Shim  ;  Yong Woo Hong  ;  Seo Ouk Bang  ;  Young Lan Kwak 
Citation
 EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, Vol.30(2) : 324-328, 2006 
Journal Title
 EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY 
ISSN
 1010-7940 
Issue Date
2006
MeSH
Aged ; Cardiotonic Agents/pharmacology ; Coronary Artery Disease/physiopathology ; Coronary Artery Disease/surgery* ; Coronary Circulation/drug effects* ; Coronary Circulation/physiology ; Female ; Hemodynamics/drug effects ; Humans ; Internal Mammary-Coronary Artery Anastomosis/methods* ; Intraoperative Care/methods ; Male ; Mammary Arteries/physiology ; Middle Aged ; Milrinone/pharmacology* ; Phosphodiesterase Inhibitors/pharmacology ; Radial Artery/physiology ; Vascular Resistance/drug effects ; Vasodilator Agents/pharmacology*
Keywords
Milrinone ; Y-graft ; Radial artery ; Internal thoracic artery ; Graft blood flow
Abstract
Objective: Milrinone has been known to dilate the internal thoracic artery (ITA) and the radial artery (RA). The effect of milrinone, however, on each graft is unclear when the left ITA (LITA) and the RA form a Y-graft. This study evaluated the changes in blood flow of a composite Y-graft in response to milrinone. Methods: Thirty-two patients undergoing an isolated coronary artery bypass graft surgery were included in this study. A Y-graft was created with an in situ LITA and free RA graft attached to the proximal side of the LITA. Graft flow was measured by opening the graft end for 30 s, and is expressed in ‘ml/min’. Graft flow and hemodynamic data were recorded before and 10 min after intravenous milrinone (50 μg/kg) administration. Results: Milrinone significantly increased the RA graft flow, measured while the LITA graft end was clamped, and total Y-graft flow. Respective graft flows were not increased by milrinone when both clamps were released simultaneously, in spite of a significant decrease in the resistance of both grafts. The ratio of flows through the RA and the LITA grafts was not changed by milrinone. Conclusion: Milrinone significantly reduced RA and LITA resistances and increased the total Y-graft flow. Milrinone might dilate each individual arterial graft to a different degree. Milrinone did not, however, change the flow ratio through the RA to LITA grafts when they were measured simultaneously. Therefore, it would not significantly divert graft flow to one side in a composite Y-graft.
Full Text
http://ejcts.oxfordjournals.org/content/30/2/324.long
DOI
10.1016/j.ejcts.2006.04.027
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Kwak, Young Lan(곽영란) ORCID logo https://orcid.org/0000-0002-2984-9927
Na, Sungwon(나성원) ORCID logo https://orcid.org/0000-0002-1170-8042
Bang, Sou Ouk(방서욱)
Shim, Yon Hee(심연희) ORCID logo https://orcid.org/0000-0003-1921-3391
Oh, Young Jun(오영준) ORCID logo https://orcid.org/0000-0002-6258-5695
Hong, Yong Woo(홍용우)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/108924
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