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새롭게 진단된 비만한 제2형 당뇨병 환자에서 Voglibose와 Glimepiride로 치료한 경우 복부 비만 및 대사적 이상에 미치는 영향에 대한 임상 비교

Other Titles
 Effects of Voglibose and Glimepiride on Adipose Tissue and Metabolic Abnormalities in Patients with Newly Diagnosed Obese Type 2 Diabetes 
 박종숙  ;  김철식  ;  김혜진  ;  박진아  ;  안철우  ;  차봉수  ;  임승길  ;  김경래  ;  이현철 
 Journal of Korean Society for the Study of Obesity (대한비만학회지), Vol.15(1) : 26-31, 2006 
Journal Title
 Journal of Korean Society for the Study of Obesity (대한비만학회지) 
Issue Date
Adiponectin ; Adipose tissue ; Glimepiride ; Voglibose
Background: To compare the effects of voglibose and glimepiride on adipose tissue and metabolic abnormalities in obese patients with newly diagnosed type 2 diabetes. Methods: Total of 40 obese patients with newly diagnosed type 2 diabetes (BMI > 25 ㎏/㎡) were included in this study. Study patients were randomized into voglibose group (n = 20) and glimepiride group (n = 20), where respective medication was administered for 12 weeks. We assessed the changes of biochemical parameters, body composition and serum adiponectin levels. Results: The voglibose treated group achieved a significant decrease in BMI, total body fat mass, and percent body fat (P < 0.05) after 12 weeks. A reduction in both subcutaneous and visceral abdominal adipose tissue area and VSR (visceral fat area/subcutaneous fat area) were noted only in the voglibose group (P < 0.05). Serum lipid profiles were similar between the two groups, except for the decrease in triglyceride levels, which were significant only in the voglibose group (P < 0.05). Serum adiponectin levels were increased only in the voglibose group (P < 0.05). Conclusions: In this study, voglibose showed to significantly decrease adipose tissue and improve adiponectin level.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Rae(김경래)
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Lee, Hyun Chul(이현철)
Lim, Sung Kil(임승길)
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
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