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흡입마취제인 desflurane의 심실근세포에서의 활동전위 연장 효과에 대한 전기생리학적인 연구

Other Titles
 Electrophysiologic Effect of Desflurane on the Prolongation of Action Potential Duration in Ventricular Myocytes 
 배선준  ;  김명희  ;  채지은  ;  김종훈  ;  민경태  ;  이민정  ;  박윤곤 
 KOREAN JOURNAL OF ANESTHESIOLOGY, Vol.50(5) : 557-566, 2006 
Journal Title
Issue Date
action potential, delayed outward K+ current ; desflurane ; inward rectifier K+current ; transient outward K+ current ; ventricular myocytes
BACKGROUND: Desflurane has been reported to prolong the QTc. Several ionic currents that contribute to the prolongation of the action potential (AP) duration were investigated using guinea pig (GP) and rat ventricular myocytes.

METHODS: The normal APs were measured in isolated GP papillary muscles at 37 ℃. Ventricular myocytes were obtained from GP and rat hearts. Both the delayed outward K+ current (IK) and the inward rectifier K+ current (IKI) were assessed using a voltage ramp protocol. A more detailed study on the IK was performed. The ICa, L was measured. In the rat ventricular myocytes, the transient outward K+ current (Ito) was obtained. All the patch clamp experiments were carried out at room temperature. The values are presented as mean ± SD.

RESULTS: 0.91 mM desflurane significantly prolonged the APD in the GP ventricular myocytes. Using a linear voltage ramp protocol, the IKI at -130 mV and the peak outward IKI) at -60 to -50 mV were not found to be significantly reduced by 0.78 and 1.23 mM desflurane, respectively. However, the peak outward IK at +60 mV was significantly reduced to 63 ± 19% and 58 ± 12% of the baseline by 0.78 and 1.23 mM desflurane, respectively. At a membrane potential of +60 mV, 0.78 and 1.23 mM desflurane reduced the Ito to 80 ± 8% and 68 ± 7%, respectively. A concentration-dependent reduction in the ICa, L was observed.

CONCLUSIONS: The prolongation of the APD induced by clinically relevant concentrations of desflurane in GP and rat ventricular myocytes is most likely the result of IK and Ito suppression.
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1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jong Hoon(김종훈)
Min, Kyeong Tae(민경태) ORCID logo https://orcid.org/0000-0002-3299-4500
Park, Wyun Kon(박윤곤)
Bai, Sun Joon(배선준) ORCID logo https://orcid.org/0000-0001-5027-3232
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