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The 11482G>A Polymorphism in the Perilipin Gene Is Associated With Weight Gain With Rosiglitazone Treatment in Type 2 Diabetes

 Eun Seok Kang  ;  Bong Soo Cha  ;  Hyeong Jin Kim  ;  Hae Jin Kim  ;  So Hun Kim  ;  Kyu Yeon Hur  ;  Hyun Joo Lee  ;  Wan Sub Shim  ;  Chul Woo Ahn  ;  Hyun Chul Lee 
 DIABETES CARE, Vol.29(6) : 1320-1324, 2006 
Journal Title
Issue Date
Carrier Proteins ; DNA Primers ; Diabetes Mellitus, Type 2/drug therapy* ; Diabetes Mellitus, Type 2/genetics* ; Genetic Variation ; Humans ; Hypoglycemic Agents/therapeutic use ; Middle Aged ; Perilipin-1 ; Phosphoproteins/genetics* ; Polymorphism, Single Nucleotide* ; Rosiglitazone ; Thiazolidinediones/therapeutic use* ; Weight Gain/genetics*
OBJECTIVE: The aim of this study was to examine the effects of perilipin gene (PLIN) polymorphisms on weight gain with rosiglitazone treatment in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS: A total of 160 type 2 diabetic patients were treated with rosiglitazone (4 mg/day) for 12 weeks in addition to their previous medications, which were unchanged. Four single nucleotide polymorphisms (SNPs) at the PLIN locus were genotyped: PLIN 6209T>C, PLIN 11482G>A, PLIN 13041A>G, and PLIN 14995A>T. RESULTS: Although fasting plasma glucose and HbA(1c) levels decreased; mean body weight increased significantly after rosiglitazone treatment. Among the four SNPs tested, only the PLIN 11482G>A polymorphism was associated with weight gain from rosiglitazone treatment. In addition, there was a significant difference in the increase in the body weight among the genotypes. Patients with the 11482A/A genotype showed less increase in body weight than those with other genotypes. CONCLUSIONS: These data suggest that genetic variations in the perilipin gene can affect weight gain associated with rosiglitazone treatment in patients with type 2 diabetes.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Eun Seok(강은석) ORCID logo https://orcid.org/0000-0002-0364-4675
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Lee, Hyun Chul(이현철)
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
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