Cited 44 times in
The 11482G>A Polymorphism in the Perilipin Gene Is Associated With Weight Gain With Rosiglitazone Treatment in Type 2 Diabetes
DC Field | Value | Language |
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dc.contributor.author | 강은석 | - |
dc.contributor.author | 안철우 | - |
dc.contributor.author | 이현철 | - |
dc.contributor.author | 차봉수 | - |
dc.date.accessioned | 2015-06-10T11:55:54Z | - |
dc.date.available | 2015-06-10T11:55:54Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0149-5992 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/108881 | - |
dc.description.abstract | OBJECTIVE: The aim of this study was to examine the effects of perilipin gene (PLIN) polymorphisms on weight gain with rosiglitazone treatment in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS: A total of 160 type 2 diabetic patients were treated with rosiglitazone (4 mg/day) for 12 weeks in addition to their previous medications, which were unchanged. Four single nucleotide polymorphisms (SNPs) at the PLIN locus were genotyped: PLIN 6209T>C, PLIN 11482G>A, PLIN 13041A>G, and PLIN 14995A>T. RESULTS: Although fasting plasma glucose and HbA(1c) levels decreased; mean body weight increased significantly after rosiglitazone treatment. Among the four SNPs tested, only the PLIN 11482G>A polymorphism was associated with weight gain from rosiglitazone treatment. In addition, there was a significant difference in the increase in the body weight among the genotypes. Patients with the 11482A/A genotype showed less increase in body weight than those with other genotypes. CONCLUSIONS: These data suggest that genetic variations in the perilipin gene can affect weight gain associated with rosiglitazone treatment in patients with type 2 diabetes. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1320~1324 | - |
dc.relation.isPartOf | DIABETES CARE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Carrier Proteins | - |
dc.subject.MESH | DNA Primers | - |
dc.subject.MESH | Diabetes Mellitus, Type 2/drug therapy* | - |
dc.subject.MESH | Diabetes Mellitus, Type 2/genetics* | - |
dc.subject.MESH | Genetic Variation | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hypoglycemic Agents/therapeutic use | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Perilipin-1 | - |
dc.subject.MESH | Phosphoproteins/genetics* | - |
dc.subject.MESH | Polymorphism, Single Nucleotide* | - |
dc.subject.MESH | Rosiglitazone | - |
dc.subject.MESH | Thiazolidinediones/therapeutic use* | - |
dc.subject.MESH | Weight Gain/genetics* | - |
dc.title | The 11482G>A Polymorphism in the Perilipin Gene Is Associated With Weight Gain With Rosiglitazone Treatment in Type 2 Diabetes | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Eun Seok Kang | - |
dc.contributor.googleauthor | Bong Soo Cha | - |
dc.contributor.googleauthor | Hyeong Jin Kim | - |
dc.contributor.googleauthor | Hae Jin Kim | - |
dc.contributor.googleauthor | So Hun Kim | - |
dc.contributor.googleauthor | Kyu Yeon Hur | - |
dc.contributor.googleauthor | Hyun Joo Lee | - |
dc.contributor.googleauthor | Wan Sub Shim | - |
dc.contributor.googleauthor | Chul Woo Ahn | - |
dc.contributor.googleauthor | Hyun Chul Lee | - |
dc.identifier.doi | 10.2337/dc05-2466 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00068 | - |
dc.contributor.localId | A02270 | - |
dc.contributor.localId | A03301 | - |
dc.contributor.localId | A03996 | - |
dc.relation.journalcode | J00721 | - |
dc.identifier.eissn | 1935-5548 | - |
dc.identifier.pmid | 16732015 | - |
dc.identifier.url | http://care.diabetesjournals.org/content/29/6/1320.long | - |
dc.contributor.alternativeName | Kang, Eun Seok | - |
dc.contributor.alternativeName | Ahn, Chul Woo | - |
dc.contributor.alternativeName | Lee, Hyun Chul | - |
dc.contributor.alternativeName | Cha, Bong Soo | - |
dc.contributor.affiliatedAuthor | Kang, Eun Seok | - |
dc.contributor.affiliatedAuthor | Ahn, Chul Woo | - |
dc.contributor.affiliatedAuthor | Lee, Hyun Chul | - |
dc.contributor.affiliatedAuthor | Cha, Bong Soo | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 29 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1320 | - |
dc.citation.endPage | 1324 | - |
dc.identifier.bibliographicCitation | DIABETES CARE, Vol.29(6) : 1320-1324, 2006 | - |
dc.identifier.rimsid | 49937 | - |
dc.type.rims | ART | - |
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