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The 11482G>A Polymorphism in the Perilipin Gene Is Associated With Weight Gain With Rosiglitazone Treatment in Type 2 Diabetes

DC Field Value Language
dc.contributor.author강은석-
dc.contributor.author안철우-
dc.contributor.author이현철-
dc.contributor.author차봉수-
dc.date.accessioned2015-06-10T11:55:54Z-
dc.date.available2015-06-10T11:55:54Z-
dc.date.issued2006-
dc.identifier.issn0149-5992-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/108881-
dc.description.abstractOBJECTIVE: The aim of this study was to examine the effects of perilipin gene (PLIN) polymorphisms on weight gain with rosiglitazone treatment in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS: A total of 160 type 2 diabetic patients were treated with rosiglitazone (4 mg/day) for 12 weeks in addition to their previous medications, which were unchanged. Four single nucleotide polymorphisms (SNPs) at the PLIN locus were genotyped: PLIN 6209T>C, PLIN 11482G>A, PLIN 13041A>G, and PLIN 14995A>T. RESULTS: Although fasting plasma glucose and HbA(1c) levels decreased; mean body weight increased significantly after rosiglitazone treatment. Among the four SNPs tested, only the PLIN 11482G>A polymorphism was associated with weight gain from rosiglitazone treatment. In addition, there was a significant difference in the increase in the body weight among the genotypes. Patients with the 11482A/A genotype showed less increase in body weight than those with other genotypes. CONCLUSIONS: These data suggest that genetic variations in the perilipin gene can affect weight gain associated with rosiglitazone treatment in patients with type 2 diabetes.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1320~1324-
dc.relation.isPartOfDIABETES CARE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHCarrier Proteins-
dc.subject.MESHDNA Primers-
dc.subject.MESHDiabetes Mellitus, Type 2/drug therapy*-
dc.subject.MESHDiabetes Mellitus, Type 2/genetics*-
dc.subject.MESHGenetic Variation-
dc.subject.MESHHumans-
dc.subject.MESHHypoglycemic Agents/therapeutic use-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPerilipin-1-
dc.subject.MESHPhosphoproteins/genetics*-
dc.subject.MESHPolymorphism, Single Nucleotide*-
dc.subject.MESHRosiglitazone-
dc.subject.MESHThiazolidinediones/therapeutic use*-
dc.subject.MESHWeight Gain/genetics*-
dc.titleThe 11482G>A Polymorphism in the Perilipin Gene Is Associated With Weight Gain With Rosiglitazone Treatment in Type 2 Diabetes-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorEun Seok Kang-
dc.contributor.googleauthorBong Soo Cha-
dc.contributor.googleauthorHyeong Jin Kim-
dc.contributor.googleauthorHae Jin Kim-
dc.contributor.googleauthorSo Hun Kim-
dc.contributor.googleauthorKyu Yeon Hur-
dc.contributor.googleauthorHyun Joo Lee-
dc.contributor.googleauthorWan Sub Shim-
dc.contributor.googleauthorChul Woo Ahn-
dc.contributor.googleauthorHyun Chul Lee-
dc.identifier.doi10.2337/dc05-2466-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00068-
dc.contributor.localIdA02270-
dc.contributor.localIdA03301-
dc.contributor.localIdA03996-
dc.relation.journalcodeJ00721-
dc.identifier.eissn1935-5548-
dc.identifier.pmid16732015-
dc.identifier.urlhttp://care.diabetesjournals.org/content/29/6/1320.long-
dc.contributor.alternativeNameKang, Eun Seok-
dc.contributor.alternativeNameAhn, Chul Woo-
dc.contributor.alternativeNameLee, Hyun Chul-
dc.contributor.alternativeNameCha, Bong Soo-
dc.contributor.affiliatedAuthorKang, Eun Seok-
dc.contributor.affiliatedAuthorAhn, Chul Woo-
dc.contributor.affiliatedAuthorLee, Hyun Chul-
dc.contributor.affiliatedAuthorCha, Bong Soo-
dc.rights.accessRightsnot free-
dc.citation.volume29-
dc.citation.number6-
dc.citation.startPage1320-
dc.citation.endPage1324-
dc.identifier.bibliographicCitationDIABETES CARE, Vol.29(6) : 1320-1324, 2006-
dc.identifier.rimsid49937-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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