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Expression of androgen receptors and inhibin/activin α and βA subunits in breast apocrine lesions

Authors
 HYO SUB SHIM  ;  WOO HEE JUNG  ;  HAERYOUNG KIM  ;  KYEONGMEE PARK  ;  NAM HOON CHO 
Citation
 APMIS, Vol.114(5) : 352-358, 2006 
Journal Title
 APMIS 
ISSN
 0903-4641 
Issue Date
2006
MeSH
Apocrine Glands/metabolism* ; Apocrine Glands/pathology ; Breast Neoplasms/metabolism* ; Breast Neoplasms/pathology ; Carcinoma in Situ/metabolism* ; Carcinoma in Situ/pathology ; Female ; Fibrocystic Breast Disease/metabolism* ; Fibrocystic Breast Disease/pathology ; Humans ; Immunohistochemistry ; Inhibin-beta Subunits/metabolism* ; Inhibins/metabolism* ; Metaplasia/metabolism* ; Metaplasia/pathology ; Papilloma, Intraductal/metabolism* ; Papilloma, Intraductal/pathology ; Receptors, Androgen/metabolism* ; Sweat Gland Neoplasms/metabolism* ; Sweat Gland Neoplasms/pathology
Keywords
Androgen receptor ; activin ; inhibin ; apocrine lesion ; breast
Abstract
The importance of androgens and their receptors inhibin and activin remains unknown for mammary epithelial cells. We investigated the role of these hormones in breast apocrine lesions (BAL) using immunohistochemistry to study androgen receptors (AR) and the inhibin/activin α and βA subunits. Forty-two cases of BAL were evaluated, including 22 cases of fibrocystic disease (FCD) showing prominent apocrine changes, 10 intraductal papillomas with extensive apocrine metaplasia, 5 cases of apocrine carcinoma in situ (CIS), and 5 cases of apocrine carcinoma. Fifty non-apocrine lesions were included as controls: 20 cases of FCD, 5 cases of DCIS, and 25 cases of invasive ductal carcinoma. AR was more frequently expressed in BAL than in non-apocrine lesions (p=0.001). AR expression was not related to tumor progression. AR showed a significant positive correlation with βA subunits (r=0.832, p<0.001), and an inverse correlation with α subunits (r=−0.233). The α and βA subunits demonstrated a significant inverse correlation with each other (r=−0.271, p=0.0048). As the expression of the α and βA subunits reflects inhibin and activin A, respectively, AR and activin A may be implicated in apocrine morphogenesis, but not in tumor progression.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0463.2006.apm_321.x/abstract
DOI
10.1111/j.1600-0463.2006.apm_321.x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Jung, Woo Hee(정우희)
Cho, Nam Hoon(조남훈) ORCID logo https://orcid.org/0000-0002-0045-6441
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/108864
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