1 494

Cited 13 times in

Expression of androgen receptors and inhibin/activin α and βA subunits in breast apocrine lesions

DC Field Value Language
dc.contributor.author정우희-
dc.contributor.author조남훈-
dc.date.accessioned2015-06-10T11:55:20Z-
dc.date.available2015-06-10T11:55:20Z-
dc.date.issued2006-
dc.identifier.issn0903-4641-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/108864-
dc.description.abstractThe importance of androgens and their receptors inhibin and activin remains unknown for mammary epithelial cells. We investigated the role of these hormones in breast apocrine lesions (BAL) using immunohistochemistry to study androgen receptors (AR) and the inhibin/activin α and βA subunits. Forty-two cases of BAL were evaluated, including 22 cases of fibrocystic disease (FCD) showing prominent apocrine changes, 10 intraductal papillomas with extensive apocrine metaplasia, 5 cases of apocrine carcinoma in situ (CIS), and 5 cases of apocrine carcinoma. Fifty non-apocrine lesions were included as controls: 20 cases of FCD, 5 cases of DCIS, and 25 cases of invasive ductal carcinoma. AR was more frequently expressed in BAL than in non-apocrine lesions (p=0.001). AR expression was not related to tumor progression. AR showed a significant positive correlation with βA subunits (r=0.832, p<0.001), and an inverse correlation with α subunits (r=−0.233). The α and βA subunits demonstrated a significant inverse correlation with each other (r=−0.271, p=0.0048). As the expression of the α and βA subunits reflects inhibin and activin A, respectively, AR and activin A may be implicated in apocrine morphogenesis, but not in tumor progression.-
dc.description.statementOfResponsibilityopen-
dc.format.extent352~358-
dc.relation.isPartOfAPMIS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHApocrine Glands/metabolism*-
dc.subject.MESHApocrine Glands/pathology-
dc.subject.MESHBreast Neoplasms/metabolism*-
dc.subject.MESHBreast Neoplasms/pathology-
dc.subject.MESHCarcinoma in Situ/metabolism*-
dc.subject.MESHCarcinoma in Situ/pathology-
dc.subject.MESHFemale-
dc.subject.MESHFibrocystic Breast Disease/metabolism*-
dc.subject.MESHFibrocystic Breast Disease/pathology-
dc.subject.MESHHumans-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHInhibin-beta Subunits/metabolism*-
dc.subject.MESHInhibins/metabolism*-
dc.subject.MESHMetaplasia/metabolism*-
dc.subject.MESHMetaplasia/pathology-
dc.subject.MESHPapilloma, Intraductal/metabolism*-
dc.subject.MESHPapilloma, Intraductal/pathology-
dc.subject.MESHReceptors, Androgen/metabolism*-
dc.subject.MESHSweat Gland Neoplasms/metabolism*-
dc.subject.MESHSweat Gland Neoplasms/pathology-
dc.titleExpression of androgen receptors and inhibin/activin α and βA subunits in breast apocrine lesions-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학)-
dc.contributor.googleauthorHYO SUB SHIM-
dc.contributor.googleauthorWOO HEE JUNG-
dc.contributor.googleauthorHAERYOUNG KIM-
dc.contributor.googleauthorKYEONGMEE PARK-
dc.contributor.googleauthorNAM HOON CHO-
dc.identifier.doi10.1111/j.1600-0463.2006.apm_321.x-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03671-
dc.contributor.localIdA03812-
dc.relation.journalcodeJ00194-
dc.identifier.eissn1600-0463-
dc.identifier.pmid16725011-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/j.1600-0463.2006.apm_321.x/abstract-
dc.subject.keywordAndrogen receptor-
dc.subject.keywordactivin-
dc.subject.keywordinhibin-
dc.subject.keywordapocrine lesion-
dc.subject.keywordbreast-
dc.contributor.alternativeNameJung, Woo Hee-
dc.contributor.alternativeNameCho, Nam Hoon-
dc.contributor.affiliatedAuthorJung, Woo Hee-
dc.contributor.affiliatedAuthorCho, Nam Hoon-
dc.rights.accessRightsnot free-
dc.citation.volume114-
dc.citation.number5-
dc.citation.startPage352-
dc.citation.endPage358-
dc.identifier.bibliographicCitationAPMIS, Vol.114(5) : 352-358, 2006-
dc.identifier.rimsid49925-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.