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The clinicopathologic significance of the expression of vascular endothelial growth factor-C in intrahepatic cholangiocarcinoma

Authors
 Byung Kyu Park  ;  Yong-Han Paik  ;  Jeong Youp Park  ;  Kyung Hwa Park  ;  Seungmin Bang  ;  Seung Woo Park  ;  Jae Bock Chung  ;  Young Nyun Park  ;  Si Young Song 
Citation
 AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS, Vol.29(2) : 138-142, 2006 
Journal Title
 AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS 
ISSN
 0277-3732 
Issue Date
2006
MeSH
Adult ; Aged ; Bile Duct Neoplasms/genetics* ; Bile Duct Neoplasms/pathology* ; Bile Ducts, Intrahepatic* ; Biomarkers, Tumor/analysis ; Blotting, Western ; Cholangiocarcinoma/genetics* ; Cholangiocarcinoma/pathology* ; Cohort Studies ; Female ; Gene Expression Profiling ; Humans ; Immunohistochemistry ; Lymphatic Metastasis* ; Male ; Middle Aged ; Neoplasm Invasiveness ; Prognosis ; Survival Analysis ; Vascular Endothelial Growth Factor C/biosynthesis*
Keywords
VEGF-C ; intrahepatic chonalgiocarcinoma ; lymphatic metastasis ; prognosis
Abstract
OBJECTIVES: Vascular endothelial growth factor-C (VEGF-C) is known to be an important lymphangiogenetic factor. Lymphatic spread is a key prognostic factor in intrahepatic cholangiocarcinoma (ICC). We studied the expression of VEGF-C in ICC tissues to clarify its clinicopathologic significance. METHODS: The expression of VEGF-C in surgical specimens obtained from 36 patients with ICC who underwent hepatic resection was examined by immunohistochemistry and Western blotting. Strong staining was defined as the presence of VEGF-C immunoreactivity in at least 50% of the tumor cells. Immunoreactivity in approximately 10% to approximately 50% of the tumor cells was considered as weak staining, and less than 10% as no staining. RESULTS: Of the 36 patients with ICC, 15 patients (41.7%) showed a strong positive result for VEGF-C. Eleven cases (30.6%) were negative and 10 cases (27.8%) showed weak immunoreactivity. VEGF-C expression was significantly correlated with lymph node metastasis (P = 0.032) and positive surgical margin (P = 0.03). Patients who had strong positive staining for VEGF-C showed significantly less favorable survival rates compared with patients who had negative or weak staining (P < 0.01). Other significant prognostic factors by univariate analysis were vascular invasion, lymph node involvement, and positive surgical margin. Multivariate analysis demonstrated that strong VEGF-C expression (P = 0.028) and vascular invasion (P = 0.021) were independent factors indicating poor prognosis. CONCLUSIONS: Our data suggest that VEGF-C expression serves as an independent and important prognostic factor in ICC patients, and it may play an important role in the lymph node metastasis of ICC.
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00000421-200604000-00006&LSLINK=80&D=ovft
DOI
10.1097/01.coc.0000204402.29830.08
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Seung Woo(박승우) ORCID logo https://orcid.org/0000-0001-8230-964X
Park, Young Nyun(박영년) ORCID logo https://orcid.org/0000-0003-0357-7967
Park, Jeong Youp(박정엽) ORCID logo https://orcid.org/0000-0003-0110-8606
Bang, Seungmin(방승민) ORCID logo https://orcid.org/0000-0001-5209-8351
Paik, Yong Han(백용한)
Song, Si Young(송시영) ORCID logo https://orcid.org/0000-0002-1417-4314
Chung, Jae Bock(정재복)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/108847
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