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The clinicopathologic significance of the expression of vascular endothelial growth factor-C in intrahepatic cholangiocarcinoma

DC Field Value Language
dc.contributor.author송시영-
dc.contributor.author정재복-
dc.contributor.author박승우-
dc.contributor.author박영년-
dc.contributor.author박정엽-
dc.contributor.author방승민-
dc.contributor.author백용한-
dc.date.accessioned2015-06-10T11:54:46Z-
dc.date.available2015-06-10T11:54:46Z-
dc.date.issued2006-
dc.identifier.issn0277-3732-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/108847-
dc.description.abstractOBJECTIVES: Vascular endothelial growth factor-C (VEGF-C) is known to be an important lymphangiogenetic factor. Lymphatic spread is a key prognostic factor in intrahepatic cholangiocarcinoma (ICC). We studied the expression of VEGF-C in ICC tissues to clarify its clinicopathologic significance. METHODS: The expression of VEGF-C in surgical specimens obtained from 36 patients with ICC who underwent hepatic resection was examined by immunohistochemistry and Western blotting. Strong staining was defined as the presence of VEGF-C immunoreactivity in at least 50% of the tumor cells. Immunoreactivity in approximately 10% to approximately 50% of the tumor cells was considered as weak staining, and less than 10% as no staining. RESULTS: Of the 36 patients with ICC, 15 patients (41.7%) showed a strong positive result for VEGF-C. Eleven cases (30.6%) were negative and 10 cases (27.8%) showed weak immunoreactivity. VEGF-C expression was significantly correlated with lymph node metastasis (P = 0.032) and positive surgical margin (P = 0.03). Patients who had strong positive staining for VEGF-C showed significantly less favorable survival rates compared with patients who had negative or weak staining (P < 0.01). Other significant prognostic factors by univariate analysis were vascular invasion, lymph node involvement, and positive surgical margin. Multivariate analysis demonstrated that strong VEGF-C expression (P = 0.028) and vascular invasion (P = 0.021) were independent factors indicating poor prognosis. CONCLUSIONS: Our data suggest that VEGF-C expression serves as an independent and important prognostic factor in ICC patients, and it may play an important role in the lymph node metastasis of ICC.-
dc.description.statementOfResponsibilityopen-
dc.format.extent138~142-
dc.relation.isPartOfAMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHBile Duct Neoplasms/genetics*-
dc.subject.MESHBile Duct Neoplasms/pathology*-
dc.subject.MESHBile Ducts, Intrahepatic*-
dc.subject.MESHBiomarkers, Tumor/analysis-
dc.subject.MESHBlotting, Western-
dc.subject.MESHCholangiocarcinoma/genetics*-
dc.subject.MESHCholangiocarcinoma/pathology*-
dc.subject.MESHCohort Studies-
dc.subject.MESHFemale-
dc.subject.MESHGene Expression Profiling-
dc.subject.MESHHumans-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHLymphatic Metastasis*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Invasiveness-
dc.subject.MESHPrognosis-
dc.subject.MESHSurvival Analysis-
dc.subject.MESHVascular Endothelial Growth Factor C/biosynthesis*-
dc.titleThe clinicopathologic significance of the expression of vascular endothelial growth factor-C in intrahepatic cholangiocarcinoma-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학)-
dc.contributor.googleauthorByung Kyu Park-
dc.contributor.googleauthorYong-Han Paik-
dc.contributor.googleauthorJeong Youp Park-
dc.contributor.googleauthorKyung Hwa Park-
dc.contributor.googleauthorSeungmin Bang-
dc.contributor.googleauthorSeung Woo Park-
dc.contributor.googleauthorJae Bock Chung-
dc.contributor.googleauthorYoung Nyun Park-
dc.contributor.googleauthorSi Young Song-
dc.identifier.doi10.1097/01.coc.0000204402.29830.08-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02035-
dc.contributor.localIdA03706-
dc.contributor.localIdA01551-
dc.contributor.localIdA01563-
dc.contributor.localIdA01647-
dc.contributor.localIdA01786-
dc.contributor.localIdA01829-
dc.relation.journalcodeJ00075-
dc.identifier.eissn1537-453X-
dc.identifier.pmid16601431-
dc.identifier.urlhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00000421-200604000-00006&LSLINK=80&D=ovft-
dc.subject.keywordVEGF-C-
dc.subject.keywordintrahepatic chonalgiocarcinoma-
dc.subject.keywordlymphatic metastasis-
dc.subject.keywordprognosis-
dc.contributor.alternativeNameSong, Si Young-
dc.contributor.alternativeNameChung, Jae Bock-
dc.contributor.alternativeNamePark, Seung Woo-
dc.contributor.alternativeNamePark, Young Nyun-
dc.contributor.alternativeNamePark, Jeong Youp-
dc.contributor.alternativeNameBang, Seung Min-
dc.contributor.alternativeNamePaik, Yong Han-
dc.contributor.affiliatedAuthorSong, Si Young-
dc.contributor.affiliatedAuthorChung, Jae Bock-
dc.contributor.affiliatedAuthorPark, Seung Woo-
dc.contributor.affiliatedAuthorPark, Young Nyun-
dc.contributor.affiliatedAuthorPark, Jeong Youp-
dc.contributor.affiliatedAuthorBang, Seung Min-
dc.contributor.affiliatedAuthorPaik, Yong Han-
dc.rights.accessRightsnot free-
dc.citation.volume29-
dc.citation.number2-
dc.citation.startPage138-
dc.citation.endPage142-
dc.identifier.bibliographicCitationAMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS, Vol.29(2) : 138-142, 2006-
dc.identifier.rimsid49915-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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