Cited 67 times in
The clinicopathologic significance of the expression of vascular endothelial growth factor-C in intrahepatic cholangiocarcinoma
DC Field | Value | Language |
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dc.contributor.author | 송시영 | - |
dc.contributor.author | 정재복 | - |
dc.contributor.author | 박승우 | - |
dc.contributor.author | 박영년 | - |
dc.contributor.author | 박정엽 | - |
dc.contributor.author | 방승민 | - |
dc.contributor.author | 백용한 | - |
dc.date.accessioned | 2015-06-10T11:54:46Z | - |
dc.date.available | 2015-06-10T11:54:46Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0277-3732 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/108847 | - |
dc.description.abstract | OBJECTIVES: Vascular endothelial growth factor-C (VEGF-C) is known to be an important lymphangiogenetic factor. Lymphatic spread is a key prognostic factor in intrahepatic cholangiocarcinoma (ICC). We studied the expression of VEGF-C in ICC tissues to clarify its clinicopathologic significance. METHODS: The expression of VEGF-C in surgical specimens obtained from 36 patients with ICC who underwent hepatic resection was examined by immunohistochemistry and Western blotting. Strong staining was defined as the presence of VEGF-C immunoreactivity in at least 50% of the tumor cells. Immunoreactivity in approximately 10% to approximately 50% of the tumor cells was considered as weak staining, and less than 10% as no staining. RESULTS: Of the 36 patients with ICC, 15 patients (41.7%) showed a strong positive result for VEGF-C. Eleven cases (30.6%) were negative and 10 cases (27.8%) showed weak immunoreactivity. VEGF-C expression was significantly correlated with lymph node metastasis (P = 0.032) and positive surgical margin (P = 0.03). Patients who had strong positive staining for VEGF-C showed significantly less favorable survival rates compared with patients who had negative or weak staining (P < 0.01). Other significant prognostic factors by univariate analysis were vascular invasion, lymph node involvement, and positive surgical margin. Multivariate analysis demonstrated that strong VEGF-C expression (P = 0.028) and vascular invasion (P = 0.021) were independent factors indicating poor prognosis. CONCLUSIONS: Our data suggest that VEGF-C expression serves as an independent and important prognostic factor in ICC patients, and it may play an important role in the lymph node metastasis of ICC. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 138~142 | - |
dc.relation.isPartOf | AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Bile Duct Neoplasms/genetics* | - |
dc.subject.MESH | Bile Duct Neoplasms/pathology* | - |
dc.subject.MESH | Bile Ducts, Intrahepatic* | - |
dc.subject.MESH | Biomarkers, Tumor/analysis | - |
dc.subject.MESH | Blotting, Western | - |
dc.subject.MESH | Cholangiocarcinoma/genetics* | - |
dc.subject.MESH | Cholangiocarcinoma/pathology* | - |
dc.subject.MESH | Cohort Studies | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gene Expression Profiling | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Lymphatic Metastasis* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Invasiveness | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Survival Analysis | - |
dc.subject.MESH | Vascular Endothelial Growth Factor C/biosynthesis* | - |
dc.title | The clinicopathologic significance of the expression of vascular endothelial growth factor-C in intrahepatic cholangiocarcinoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | Byung Kyu Park | - |
dc.contributor.googleauthor | Yong-Han Paik | - |
dc.contributor.googleauthor | Jeong Youp Park | - |
dc.contributor.googleauthor | Kyung Hwa Park | - |
dc.contributor.googleauthor | Seungmin Bang | - |
dc.contributor.googleauthor | Seung Woo Park | - |
dc.contributor.googleauthor | Jae Bock Chung | - |
dc.contributor.googleauthor | Young Nyun Park | - |
dc.contributor.googleauthor | Si Young Song | - |
dc.identifier.doi | 10.1097/01.coc.0000204402.29830.08 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02035 | - |
dc.contributor.localId | A03706 | - |
dc.contributor.localId | A01551 | - |
dc.contributor.localId | A01563 | - |
dc.contributor.localId | A01647 | - |
dc.contributor.localId | A01786 | - |
dc.contributor.localId | A01829 | - |
dc.relation.journalcode | J00075 | - |
dc.identifier.eissn | 1537-453X | - |
dc.identifier.pmid | 16601431 | - |
dc.identifier.url | http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00000421-200604000-00006&LSLINK=80&D=ovft | - |
dc.subject.keyword | VEGF-C | - |
dc.subject.keyword | intrahepatic chonalgiocarcinoma | - |
dc.subject.keyword | lymphatic metastasis | - |
dc.subject.keyword | prognosis | - |
dc.contributor.alternativeName | Song, Si Young | - |
dc.contributor.alternativeName | Chung, Jae Bock | - |
dc.contributor.alternativeName | Park, Seung Woo | - |
dc.contributor.alternativeName | Park, Young Nyun | - |
dc.contributor.alternativeName | Park, Jeong Youp | - |
dc.contributor.alternativeName | Bang, Seung Min | - |
dc.contributor.alternativeName | Paik, Yong Han | - |
dc.contributor.affiliatedAuthor | Song, Si Young | - |
dc.contributor.affiliatedAuthor | Chung, Jae Bock | - |
dc.contributor.affiliatedAuthor | Park, Seung Woo | - |
dc.contributor.affiliatedAuthor | Park, Young Nyun | - |
dc.contributor.affiliatedAuthor | Park, Jeong Youp | - |
dc.contributor.affiliatedAuthor | Bang, Seung Min | - |
dc.contributor.affiliatedAuthor | Paik, Yong Han | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 29 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 138 | - |
dc.citation.endPage | 142 | - |
dc.identifier.bibliographicCitation | AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS, Vol.29(2) : 138-142, 2006 | - |
dc.identifier.rimsid | 49915 | - |
dc.type.rims | ART | - |
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