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Relationship between bilateral temporal hypometabolism and EEG findings for mesial temporal lobe epilepsy: Analysis of

Authors
 Mi Ae Kim  ;  Kyoung Heo  ;  Min Kyung Choo  ;  Jung Hee Cho  ;  Soo Chul Park  ;  Jong Doo Lee  ;  Mijin Yun  ;  Hae-Jeong Park  ;  Byung In Lee 
Citation
 SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, Vol.15(1) : 56-63, 2006 
Journal Title
 SEIZURE-EUROPEAN JOURNAL OF EPILEPSY 
ISSN
 1059-1311 
Issue Date
2006
MeSH
Adolescent ; Adult ; Amobarbital ; Anterior Temporal Lobectomy ; Child ; Electroencephalography* ; Epilepsy, Temporal Lobe/metabolism* ; Epilepsy, Temporal Lobe/pathology ; Epilepsy, Temporal Lobe/surgery ; Female ; Fluorodeoxyglucose F18 ; Humans ; Image Processing, Computer-Assisted* ; Male ; Memory ; Positron-Emission Tomography/methods* ; Treatment Outcome
Keywords
18F-FDG PET ; Statistical parametric mapping ; EEG ; Mesial temporal lobe epilepsy
Abstract
PURPOSE: To investigate the clinical significance of bilateral temporal hypometabolism (BTH) for patients with mesial temporal lobe epilepsy (MTLE) by using statistical parametric mapping (SPM). METHODS: Interictal 18F-FDG PET scans were performed for 29 patients with surgically treated MTLE. Clinical data, interictal epileptiform discharges (IEDs), ictal scalp EEG and intracarotid amobarbital test (IAT) were analyzed. To assess an 18F-FDG PET image, an SPM analysis as well as visual interpretation were applied. RESULTS: In 9 of 29 patients, the 18F-FDG PET scan revealed BTH by the SPM analysis, while only 3 patients showed BTH by the visual assessment. When the patients were classified into the unilateral temporal hypometabolism (UTH) and BTH groups based on the SPM results, bitemporal IEDs occurred significantly more frequently in the BTH group than in the UTH group (66.7% versus 22.2%). Bilateral independent seizure onset seen on the scalp EEG and bitemporal epilepsy were present only in the BTH group. Lateralized ictal onset was present less frequently in the BTH group than in the UTH group (44.4% versus 83.3%). There was no statistically significant difference in age at onset, duration of epilepsy, generalized seizure, history of febrile convulsion and CNS infection, lateralization throughout the whole tracing, lateralization on the IAT test, and surgical outcome between the UTH and BTH groups. CONCLUSION: Bilaterality of the EEG findings correlated with BTH on 18F-FDG PET by the SPM method. Our results suggest that analysis of 18F-FDG PET by using SPM may have a role in predicting those patients with bitemporal excitability or bitemporal independent epileptogenicity, and these patients should be monitored carefully.
Files in This Item:
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DOI
10.1016/j.seizure.2005.11.007
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Park, Soo Chul(박수철)
Park, Hae Jeong(박해정) ORCID logo https://orcid.org/0000-0002-4633-0756
Yun, Mi Jin(윤미진) ORCID logo https://orcid.org/0000-0002-1712-163X
Lee, Byung In(이병인)
Lee, Jong Doo(이종두)
Heo, Kyoung(허경)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/108764
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