Cited 2 times in
Repetitive dextromethorphan at adolescence affects water maze learning in female rats
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이서울 | - |
dc.contributor.author | 이주영 | - |
dc.contributor.author | 장정원 | - |
dc.contributor.author | 조희정 | - |
dc.date.accessioned | 2015-06-10T11:51:18Z | - |
dc.date.available | 2015-06-10T11:51:18Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0020-7454 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/108743 | - |
dc.description.abstract | Effects of repetitive dextromethorphan at adolescence on a spatial learning of rats were investigated. Rats received 10 daily injections of dextromethorphan (40 mg/kg) from postnatal day 28 thru 37, and were then subjected to the Morris water maze task from day 38. Significant impairments were found in the probe trial and the reversal training of the maze learning in the female rats, but not in males, treated with dextromethorphan. This result suggests that repetitive dextromethorphan, that is, abuse of dextromethorphan, at adolescence may induce deficits in the hippocampus-based memory function, perhaps more obviously in females | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 91~101 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF NEUROSCIENCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Age Factors | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Dextromethorphan/administration & dosage* | - |
dc.subject.MESH | Drug Administration Schedule | - |
dc.subject.MESH | Excitatory Amino Acid Antagonists/administration & dosage* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Maze Learning/drug effects* | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors* | - |
dc.subject.MESH | Reversal Learning/drug effects* | - |
dc.subject.MESH | Sex Factors | - |
dc.title | Repetitive dextromethorphan at adolescence affects water maze learning in female rats | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pharmacology (약리학) | - |
dc.contributor.googleauthor | Hee Jeong Cho | - |
dc.contributor.googleauthor | Jae Goo Kim | - |
dc.contributor.googleauthor | Joo Young Lee | - |
dc.contributor.googleauthor | Seoul Lee | - |
dc.contributor.googleauthor | Jeong Won Jahng | - |
dc.identifier.doi | 10.1080/00207450500341415 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02848 | - |
dc.contributor.localId | A03467 | - |
dc.contributor.localId | A03946 | - |
dc.contributor.localId | A03159 | - |
dc.relation.journalcode | J01136 | - |
dc.identifier.eissn | 1563-5279 | - |
dc.identifier.pmid | 16393876 | - |
dc.identifier.url | http://informahealthcare.com/doi/abs/10.1080/00207450500341415 | - |
dc.subject.keyword | adolescence | - |
dc.subject.keyword | drug abuse | - |
dc.subject.keyword | hippocampus | - |
dc.subject.keyword | memory | - |
dc.subject.keyword | NMDA (N-methyl-D-aspartate) receptor | - |
dc.subject.keyword | rats | - |
dc.contributor.alternativeName | Lee, Seoul | - |
dc.contributor.alternativeName | Lee, Joo Young | - |
dc.contributor.alternativeName | Jahng, Jeong Won | - |
dc.contributor.alternativeName | Cho, Hi Jung | - |
dc.contributor.affiliatedAuthor | Lee, Seoul | - |
dc.contributor.affiliatedAuthor | Jahng, Jeong Won | - |
dc.contributor.affiliatedAuthor | Cho, Hi Jung | - |
dc.contributor.affiliatedAuthor | Lee, Joo Young | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 116 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 91 | - |
dc.citation.endPage | 101 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF NEUROSCIENCE, Vol.116(2) : 91-101, 2006 | - |
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