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Synthesis of novel fluorescent magnetic nanoparticles as bimodal imaging agents

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dc.contributor.author서진석-
dc.contributor.author양재문-
dc.contributor.author허용민-
dc.date.accessioned2015-05-19T17:38:22Z-
dc.date.available2015-05-19T17:38:22Z-
dc.date.issued2008-
dc.identifier.issn0168-1656-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/108531-
dc.description.abstractInorganic/organic nanoparticles are emerging probes for the biomedical applications. Especially, magnetic nanocrystals (MNCs, Fe3O4) have recently demonstrated excellent magnetic properties and low toxicity that can be applied to bio-medical applications such as magnetic resonance (MR) imaging systems (Lee et al., 2000; Yang et al., 2007). Due to advantageous bimodal imaging for synergistic target disease diagnosis, moreover, fluorescent-dye as optical imaging agents was introduced to MNCs and well-tailored fluorescent magnetic nanoparticles (FMNs) were synthesized using polymethyl methacrylate (PMMA). Inorganic/organic nanocomposites containing 10 nm of MNCs (Fig. 1a) and fluorescent rhodamine B were fabricated by a simple way (nano-emulsion method) using PMMA as substrate. The prepared nanocomposites have a homogeneous size of 80 nm (Fig. 1b). In the spin–spin relaxation time (T2) weighted MR images, FMNs solution presented high relaxivity coefficient (720.62 mM−1 s−1) because large amounts of magnetic components incorporate with the PMMA (Fig. 1c). Furthermore, the potentials of FMNs as optical imaging agents were estimated using optical imaging equipments. FMNs were successfully gathered by external magnetic field and that was visualized with color maps (Fig. 1d). Conclusively, FMNs, as bimodal imaging agents, not only demonstrated excellent sensitivity as MR probes but also produced clear fluorescent intensity as optical imaging probes-
dc.description.statementOfResponsibilityopen-
dc.format.extentS195~S195-
dc.relation.isPartOfJOURNAL OF BIOTECHNOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleSynthesis of novel fluorescent magnetic nanoparticles as bimodal imaging agents-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiology (영상의학)-
dc.contributor.googleauthorJoseph Park-
dc.contributor.googleauthorJaemoon Yang-
dc.contributor.googleauthorJin-Suck Suh-
dc.contributor.googleauthorYong-Min Huh-
dc.contributor.googleauthorSeungjoo Haam-
dc.identifier.doi10.1016/j.jbiotec.2008.07.1837-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02315-
dc.contributor.localIdA01916-
dc.contributor.localIdA04359-
dc.relation.journalcodeJ01274-
dc.identifier.eissn1873-4863-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0168165608021299-
dc.contributor.alternativeNameSuh, Jin Suck-
dc.contributor.alternativeNameYang, Jae Moon-
dc.contributor.alternativeNameHuh, Yong Min-
dc.contributor.affiliatedAuthorYang, Jae Moon-
dc.contributor.affiliatedAuthorSuh, Jin Suck-
dc.contributor.affiliatedAuthorHuh, Yong Min-
dc.rights.accessRightsnot free-
dc.citation.volume136-
dc.citation.numbersuppl-
dc.citation.startPage195-
dc.identifier.bibliographicCitationJOURNAL OF BIOTECHNOLOGY, Vol.136(suppl) : 195, 2008-
dc.identifier.rimsid37061-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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