570 541

Cited 0 times in

Flutamide의 항경련 작용에 대한 in vitro 연구

Other Titles
 Anticonvulsant Effect of Flutamide in vitro Seizure Model 
Authors
 김원주  ;  이수연  ;  이병인 
Citation
 Journal of Korean Epilepsy Society (대한간질학회지), Vol.12(2) : 92-95, 2008 
Journal Title
Journal of Korean Epilepsy Society(대한간질학회지)
ISSN
 1226-6965 
Issue Date
2008
Keywords
Flutamide ; Seizure ; Benzodiazepine
Abstract
PURPOSE: Flutamide (4-nitro-3-t-trifluoromethyl-isobutyranilide) is an androgen-receptor antagonist with typical antiandrogenic effect, used to treat androgen-dependent disorders such as prostate cancer. However, some reports noted that flutamide has direct effects to neuronal cells. It has been shown to retard the development of electrical kindling in rats. METHODS: We used the chemoconvulsant 4-aminopyridine (4-AP) and picrotoxin (PTX) in the in vitro hippocampal slice model to determine of flutamide for the suppression of epileptiform discharges. Extracellular field potential recordings were obtained from the CA3 pyramidal layer of hippocampus. RESULTS: The concentration of 30 and 100 micrometer flutamide suppressed the whole mean number of epileptiform discharges to 57.8% and 66.8% each compared with the 4-AP only slices. In 100 micrometer PTX, 10 and 30 micrometer flutamide suppressed the whole mean number of epileptiform discharges to 56.6% and 82.5% each. Intermixed with flumazenil, the anticonvulsant effect of flutamide was decreased. CONCLUSIONS: Flutamide suppressed epileptiform discharges induced by 4-AP and PTX in vitro seizure model. It suggests that flutamide influence to anti-epileptic activity by benzodiazepine site of the GABAA receptor.
Files in This Item:
T200805061.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Won Ju(김원주)
Lee, Byung In(이병인)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/108334
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links