Cited 36 times in
In situ detection of live cancer cells by using bioprobes based on Au nanoparticles
DC Field | Value | Language |
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dc.contributor.author | 서진석 | - |
dc.contributor.author | 양재문 | - |
dc.contributor.author | 허용민 | - |
dc.date.accessioned | 2015-05-19T17:28:18Z | - |
dc.date.available | 2015-05-19T17:28:18Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0743-7463 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/108210 | - |
dc.description.abstract | We fabricate the high-performance probes based on Au nanoparticles (AuNP) for detection of live cancer cell. AuNP were synthesized with narrow sized distribution (ca. 10 nm) by Au salt reduction method and deposited onto the aminated substrate as a cross-linker and hot spot. Herein, AuNP has enabled the easy and efficient immobilization of the antibody (Cetuximab), which can selectively interact with epidermal growth factor receptor (EGFR) on the surface of epidermal cancer, as detecting moiety onto the AuNP-deposited substrate without nanolithography process. After conjugation of Cetuximab with AuNP-deposited substrate, Cetuximab-conjugated probe as a live cancer cell detector (LCCD) could detect EGFR-highexpressed A431 cells related to epithelial cancer with 54-times larger specificity and sensitivity in comparison with EGFR-deficient MCF7 cells. This implies that AuNP-based probes demonstrate abundant potentials for detection and separation of small biomolecules, cells and other chemicals | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 12112~12115 | - |
dc.relation.isPartOf | LANGMUIR | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Gold/chemistry* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Metal Nanoparticles* | - |
dc.subject.MESH | Microscopy, Atomic Force | - |
dc.subject.MESH | Microscopy, Electron, Transmission | - |
dc.subject.MESH | Microscopy, Fluorescence | - |
dc.subject.MESH | Molecular Probes* | - |
dc.subject.MESH | Neoplasms/diagnosis* | - |
dc.subject.MESH | Neoplasms/pathology | - |
dc.subject.MESH | Spectrophotometry, Ultraviolet | - |
dc.title | In situ detection of live cancer cells by using bioprobes based on Au nanoparticles | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학) | - |
dc.contributor.googleauthor | Jaemoon Yang | - |
dc.contributor.googleauthor | Kilho Eom | - |
dc.contributor.googleauthor | Eun-Kyung Lim | - |
dc.contributor.googleauthor | Jinsung Park | - |
dc.contributor.googleauthor | Yoonah Kang | - |
dc.contributor.googleauthor | Dae Sung Yoon | - |
dc.contributor.googleauthor | Sungsoo Na | - |
dc.contributor.googleauthor | Eui Kwan Koh | - |
dc.contributor.googleauthor | Jin-Suck Suh | - |
dc.contributor.googleauthor | Yong-Min Huh | - |
dc.contributor.googleauthor | Tae Yun Kwon | - |
dc.contributor.googleauthor | Seungjoo Haam | - |
dc.identifier.doi | 10.1021/la802184m | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02315 | - |
dc.contributor.localId | A01916 | - |
dc.contributor.localId | A04359 | - |
dc.relation.journalcode | J02155 | - |
dc.identifier.eissn | 1520-5827 | - |
dc.identifier.pmid | 18826263 | - |
dc.identifier.url | http://pubs.acs.org/doi/abs/10.1021/la802184m | - |
dc.subject.keyword | Cell Line, Tumor | - |
dc.subject.keyword | Gold/chemistry* | - |
dc.subject.keyword | Humans | - |
dc.subject.keyword | Metal Nanoparticles* | - |
dc.subject.keyword | Microscopy, Atomic Force | - |
dc.subject.keyword | Microscopy, Electron, Transmission | - |
dc.subject.keyword | Microscopy, Fluorescence | - |
dc.subject.keyword | Molecular Probes* | - |
dc.subject.keyword | Neoplasms/diagnosis* | - |
dc.subject.keyword | Neoplasms/pathology | - |
dc.subject.keyword | Spectrophotometry, Ultraviolet | - |
dc.contributor.alternativeName | Suh, Jin Suck | - |
dc.contributor.alternativeName | Yang, Jae Moon | - |
dc.contributor.alternativeName | Huh, Yong Min | - |
dc.contributor.affiliatedAuthor | Yang, Jae Moon | - |
dc.contributor.affiliatedAuthor | Suh, Jin Suck | - |
dc.contributor.affiliatedAuthor | Huh, Yong Min | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 24 | - |
dc.citation.number | 21 | - |
dc.citation.startPage | 12112 | - |
dc.citation.endPage | 12115 | - |
dc.identifier.bibliographicCitation | LANGMUIR, Vol.24(21) : 12112-12115, 2008 | - |
dc.identifier.rimsid | 35253 | - |
dc.type.rims | ART | - |
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