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8p11 myeloproliferative syndrome preceded by t(8;9)(p11;q33), CEP110/FGFR1 fusion transcript: morphologic, molecular, and cytogenetic characterization of myeloid neoplasms associated with eosinophilia and FGFR1 abnormality.

Authors
 Tae Sung Park  ;  Jaewoo Song  ;  Jin Seok Kim  ;  Woo Ick Yang  ;  Sungwook Song  ;  Sue Jung Kim  ;  Borum Suh  ;  Jong Rak Choi 
Citation
 CANCER GENETICS AND CYTOGENETICS , Vol.181(2) : 93-99, 2008 
Journal Title
 CANCER GENETICS AND CYTOGENETICS 
ISSN
 0165-4608 
Issue Date
2008
MeSH
Adult ; Chromosomes, Human, Pair 8* ; Chromosomes, Human, Pair 9* ; Cytogenetic Analysis ; Eosinophilia/genetics* ; Eosinophilia/pathology ; Humans ; Karyotyping ; Leukemia/genetics ; Leukemia/pathology ; Male ; Molecular Sequence Data ; Myeloproliferative Disorders/diagnosis ; Myeloproliferative Disorders/genetics* ; Myeloproliferative Disorders/pathology ; Oncogene Proteins, Fusion/genetics* ; Receptor, Fibroblast Growth Factor, Type 1/genetics* ; Syndrome ; Translocation, Genetic*
Keywords
Adult ; Chromosomes, Human, Pair 8* ; Chromosomes, Human, Pair 9* ; Cytogenetic Analysis ; Eosinophilia/genetics* ; Eosinophilia/pathology ; Humans ; Karyotyping ; Leukemia/genetics ; Leukemia/pathology ; Male ; Molecular Sequence Data ; Myeloproliferative Disorders/diagnosis ; Myeloproliferative Disorders/genetics* ; Myeloproliferative Disorders/pathology ; Oncogene Proteins, Fusion/genetics* ; Receptor, Fibroblast Growth Factor, Type 1/genetics* ; Syndrome ; Translocation, Genetic*
Abstract
We report a rare case of t(8;9)(p11;q33) in a patient with 8p11 myeloproliferative syndrome (EMS) that was preceded by centrosomal protein 110kDa (CEP110; previously CEP1)/fibroblast growth factor receptor 1 (FGFR1) fusion transcript. A 36-year-old man was brought to Severance Hospital with a nasopharyngeal mass and eosinophilia. Biopsy of the left tonsil and nasopharynx revealed diffuse infiltration of atypical lymphoid cells, and he was diagnosed with precursor T-cell lymphoma with hypereosinophilic syndrome. Two months later, chromosome study revealed a 46,XY,t(8;9)(p11;q33) karyotype, and the CEP110/FGFR1 fusion transcript was detected by reverse transcription-polymerase chain reaction (RT-PCR) in both this and the previous bone marrow specimen. Timely molecular and cytogenetic tests are of value for diagnosis and treatment of the newly classified "myeloid neoplasms associated with clonal eosinophilic disorders" (according to 2008 World Health Organization criteria).
Full Text
http://www.sciencedirect.com/science/article/pii/S0165460807007674#
DOI
10.1016/j.cancergencyto.2007.11.011
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jin Seok(김진석) ORCID logo https://orcid.org/0000-0001-8986-8436
Song, Jae Woo(송재우) ORCID logo https://orcid.org/0000-0002-1877-5731
Yang, Woo Ick(양우익) ORCID logo https://orcid.org/0000-0002-6084-5019
Choi, Jong Rak(최종락) ORCID logo https://orcid.org/0000-0002-0608-2989
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/108157
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