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Cited 17 times in

Neuroradiologic findings in children with mitochondrial disorder: correlation with mitochondrial respiratory chain defects.

DC FieldValueLanguage
dc.contributor.author김동익-
dc.contributor.author김응엽-
dc.contributor.author김진아-
dc.contributor.author김흥동-
dc.contributor.author이승구-
dc.contributor.author이영목-
dc.contributor.author이준수-
dc.date.accessioned2015-05-19T17:26:27Z-
dc.date.available2015-05-19T17:26:27Z-
dc.date.issued2008-
dc.identifier.issn0938-7994-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/108152-
dc.description.abstractMitochondrial disorders are a heterogeneous group of disorders affecting energy metabolism that can present at any age with a wide variety of clinical symptoms. We investigated brain magnetic resonance (MR) findings in 40 children with defects of the mitochondrial respiratory chain (MRC) complex and correlated them with the type of MRC defects. Enrolled were 40 children with MRC defects in biochemical enzyme assay of the muscle specimen. Twenty-one children were found to have classical syndromes of mitochondrial disorders and 19 children presented nonspecific mitochondrial encephalomyopathies. Their brain MR imaging findings were retrospectively reviewed and correlated with the biochemical defect in the MRC complex. Children with MRC defects showed various neuroradiologic features on brain MR imaging that resulted from a complex genetic background and a heterogeneous phenotype. Rapid progression of atrophy involving all structures of the brain with variable involvement of deep gray and white matter are the most frequent MR findings in children with MRC defects in both classical syndromes of mitochondrial disorder and nonspecific mitochondrial encephalomyopathies. The type of biochemical defect in the MRC complex enzyme did not correlate with brain MR findings in child patients-
dc.description.statementOfResponsibilityopen-
dc.format.extent1741~1748-
dc.relation.isPartOfEUROPEAN RADIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHBrain/pathology*-
dc.subject.MESHBrain Diseases/pathology*-
dc.subject.MESHChild-
dc.subject.MESHChild, Preschool-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHInfant-
dc.subject.MESHMagnetic Resonance Imaging/methods*-
dc.subject.MESHMale-
dc.subject.MESHMitochondrial Diseases/diagnosis*-
dc.subject.MESHSensitivity and Specificity-
dc.subject.MESHStatistics as Topic-
dc.titleNeuroradiologic findings in children with mitochondrial disorder: correlation with mitochondrial respiratory chain defects.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아과학)-
dc.contributor.googleauthorJinna Kim-
dc.contributor.googleauthorSeung-Koo Lee-
dc.contributor.googleauthorEung Yeop Kim-
dc.contributor.googleauthorDong Ik Kim-
dc.contributor.googleauthorYoung-Mock Lee-
dc.contributor.googleauthorJoon Soo Lee-
dc.contributor.googleauthorHeung Dong Kim-
dc.identifier.doi10.1007/s00330-008-0921-1-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01022-
dc.contributor.localIdA00408-
dc.contributor.localIdA00832-
dc.contributor.localIdA01208-
dc.contributor.localIdA02912-
dc.contributor.localIdA02955-
dc.contributor.localIdA03177-
dc.relation.journalcodeJ00851-
dc.identifier.eissn1432-1084-
dc.identifier.pmid18389251-
dc.identifier.urlhttp://link.springer.com/article/10.1007%2Fs00330-008-0921-1-
dc.subject.keywordBrain-
dc.subject.keywordMagnetic resonance imaging-
dc.subject.keywordMitochondrial disorder-
dc.contributor.alternativeNameKim, Dong Ik-
dc.contributor.alternativeNameKim, Eung Yeop-
dc.contributor.alternativeNameKim, Jinna-
dc.contributor.alternativeNameKim, Heung Dong-
dc.contributor.alternativeNameLee, Seung Koo-
dc.contributor.alternativeNameLee, Young Mock-
dc.contributor.alternativeNameLee, Joon Soo-
dc.contributor.affiliatedAuthorKim, Jinna-
dc.contributor.affiliatedAuthorKim, Dong Ik-
dc.contributor.affiliatedAuthorKim, Eung Yeop-
dc.contributor.affiliatedAuthorKim, Heung Dong-
dc.contributor.affiliatedAuthorLee, Seung Koo-
dc.contributor.affiliatedAuthorLee, Young Mock-
dc.contributor.affiliatedAuthorLee, Joon Soo-
dc.rights.accessRightsnot free-
dc.citation.volume18-
dc.citation.number8-
dc.citation.startPage1741-
dc.citation.endPage1748-
dc.identifier.bibliographicCitationEUROPEAN RADIOLOGY, Vol.18(8) : 1741-1748, 2008-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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