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Effects of fentanyl pretreatment on the QTc interval during propofol induction

Authors
 D. J. Chang  ;  T. D. Kweon  ;  S. B. Nam  ;  J. S. Lee  ;  C. S. Shin  ;  C. H. Park  ;  D. W. Han 
Citation
 Anaesthesia, Vol.63(10) : 1056-1060, 2008 
Journal Title
 Anaesthesia 
ISSN
 0003-2409 
Issue Date
2008
MeSH
Adult ; Anesthesia, Intravenous/methods ; Anesthetics, Intravenous/therapeutic use* ; Blood Pressure/drug effects ; Double-Blind Method ; Electrocardiography/methods ; Female ; Fentanyl/therapeutic use* ; Heart Rate/drug effects ; Humans ; Intraoperative Complications/prevention & control* ; Intubation, Intratracheal/adverse effects ; Laryngoscopy/adverse effects ; Long QT Syndrome/etiology ; Long QT Syndrome/prevention & control* ; Male ; Middle Aged ; Monitoring, Intraoperative/methods ; Propofol*
Keywords
Adult ; Anesthesia, Intravenous/methods ; Anesthetics, Intravenous/therapeutic use* ; Blood Pressure/drug effects ; Double-Blind Method ; Electrocardiography/methods ; Female ; Fentanyl/therapeutic use* ; Heart Rate/drug effects ; Humans ; Intraoperative Complications/prevention & control* ; Intubation, Intratracheal/adverse effects ; Laryngoscopy/adverse effects ; Long QT Syndrome/etiology ; Long QT Syndrome/prevention & control* ; Male ; Middle Aged ; Monitoring, Intraoperative/methods ; Propofol*
Abstract
Prolongation of the corrected QT (QTc) interval is associated with various anaesthetic drugs. The QTc prolongation may become more exacerbated during laryngoscopy and intubation, which is possibly caused by sympathetic stimulation. The aim of this study was to investigate the effects of fentanyl on the QTc interval during propofol induction in healthy patients. The patients were randomly allocated to receive either fentanyl (n = 25) or saline (n = 25) before induction. The QTc interval was significantly prolonged immediately after intubation in control group compared to preceding values, but it did not change in the fentanyl group. The number of patients with the prolonged QTc interval exceeding 20 ms immediately after intubation compared to the baseline values was 14 in the control group and seven in the fentanyl group. In conclusion, pretreatment with fentanyl 2 microg x kg(-1) significantly attenuated QTc prolongation associated with laryngoscopy and tracheal intubation during propofol induction.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2044.2008.05559.x/abstract
DOI
10.1111/j.1365-2044.2008.05559.x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Kweon, Tae Dong(권태동) ORCID logo https://orcid.org/0000-0002-5451-1856
Nam, Sang Beom(남상범) ORCID logo https://orcid.org/0000-0002-9704-1866
Shin, Cheung Soo(신증수) ORCID logo https://orcid.org/0000-0001-7829-8458
Lee, Jong Seok(이종석) ORCID logo https://orcid.org/0000-0002-7945-2530
Chang, Dong Jin(장동진)
Han, Dong Woo(한동우) ORCID logo https://orcid.org/0000-0002-8757-663X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/108119
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