Cited 131 times in
Multifunctional Magnetic Gold Nanocomposites: Human Epithelial Cancer Detection via Magnetic Resonance Imaging and Localized Synchronous Therapy
DC Field | Value | Language |
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dc.contributor.author | 서진석 | - |
dc.contributor.author | 양재문 | - |
dc.contributor.author | 윤호근 | - |
dc.contributor.author | 허용민 | - |
dc.date.accessioned | 2015-05-19T17:24:49Z | - |
dc.date.available | 2015-05-19T17:24:49Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 1616-301X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/108100 | - |
dc.description.abstract | Novel multifunctional magnetic gold nanocomposites (MGNCs) were synthesized for synchronous cancer therapy and diagnosis via magnetic resonance imaging (MRI). The MGNCs consist of magnetic kernels (aggregates of ultra-sensitive MnFe2O4 magnetic nanocrystals wrapped in polymer) as effective MR contrast agents and silica–gold nanocomposites as hyperthermal therapeutic agents. A therapeutic antibody, Erbitux (ERB), was conjugated for specific tumor cell targeting both to localize the near-IR laser beam and to image their events through MRI. ERB-conjugated MGNCs selectively recognize the target cancer cell lines. Fluorescence images and MRI analysis show that the MGNCs are effectively taken up by the cells. ERB-conjugated MGNCs have an excellent synchronous therapeutic efficacy as a result of the therapeutic antibody and near-IR laser-induced surface plasmon resonance. Consequently, MGNCs clearly demonstrate selective imaging and treatment of human epithelial cancer simultaneously. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 258~264 | - |
dc.relation.isPartOf | ADVANCED FUNCTIONAL MATERIALS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Multifunctional Magnetic Gold Nanocomposites: Human Epithelial Cancer Detection via Magnetic Resonance Imaging and Localized Synchronous Therapy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Biochemistry & Molecular Biology (생화학,분자생물학) | - |
dc.contributor.googleauthor | Jaewon Lee | - |
dc.contributor.googleauthor | Jaemoon Yang | - |
dc.contributor.googleauthor | Hyunju Ko | - |
dc.contributor.googleauthor | Seung Jae Oh | - |
dc.contributor.googleauthor | Jinyoung Kang | - |
dc.contributor.googleauthor | Joo-Hiuk Son | - |
dc.contributor.googleauthor | Kwangyeol Lee | - |
dc.contributor.googleauthor | Sang-Wha Lee | - |
dc.contributor.googleauthor | Ho-Geun Yoon | - |
dc.contributor.googleauthor | Jin-Suck Suh | - |
dc.contributor.googleauthor | Yong-Min Huh | - |
dc.contributor.googleauthor | Seungjoo Haam | - |
dc.identifier.doi | 10.1002/adfm.200700482 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01916 | - |
dc.contributor.localId | A02625 | - |
dc.contributor.localId | A04359 | - |
dc.contributor.localId | A02315 | - |
dc.relation.journalcode | J00041 | - |
dc.identifier.eissn | 1616-3028 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1002/adfm.200700482/abstract | - |
dc.contributor.alternativeName | Suh, Jin Suck | - |
dc.contributor.alternativeName | Yang, Jae Moon | - |
dc.contributor.alternativeName | Yoon, Ho Geun | - |
dc.contributor.alternativeName | Huh, Yong Min | - |
dc.contributor.affiliatedAuthor | Suh, Jin Suck | - |
dc.contributor.affiliatedAuthor | Yoon, Ho Geun | - |
dc.contributor.affiliatedAuthor | Huh, Yong Min | - |
dc.contributor.affiliatedAuthor | Yang, Jae Moon | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 18 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 258 | - |
dc.citation.endPage | 264 | - |
dc.identifier.bibliographicCitation | ADVANCED FUNCTIONAL MATERIALS, Vol.18(2) : 258-264, 2008 | - |
dc.identifier.rimsid | 35182 | - |
dc.type.rims | ART | - |
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