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교감신경 의존적 및 비의존적 신경병증 통증 쥐 모델 후근신경절에서 Ca++ Channel α2δ Subunit와 TRPM8 발현

Other Titles
 The Expression of the Ca++ Channel α2δ Subunit and TRPM8 in the Dorsal Root Ganglion of Sympathetically Maintained Pain and Sympathetic Independent Pain Rat Models 
 한동우  ;  권태동  ;  김연아  ;  최종범  ;  이윤우 
 Korean Journal of Pain (대한통증학회지), Vol.21(1) : 11-17, 2008 
Journal Title
Korean Journal of Pain (대한통증학회지)
Issue Date
α2δ subunit ; dorsal root ganglion ; SIP ; SMP ; TRPM8
Peripheral nerve injury induces up-regulation of the calcium channel alpha2delta (α2δ) subunit and TRPM8 in the dorsal root ganglion (DRG) which might contribute to allodynia development. We investigated the expression of the α2δ subunit and TRPM8 in the DRG of sympathetically maintained pain (SMP) and sympathetic independent pain (SIP) rat model.

For the SMP model, the L5 and L6 spinal nerves were ligated tightly distal to the DRG. For the SIP model, the tibial and sural nerves were transected, while the common peroneal nerve was spared. After a 7 day postoperative period, tactile and cold allodynia were assessed using von Frey filaments and acetone drops, respectively. Expression of the α2δ subunit and TRPM8 in the L5 and L6 DRG were subsequently examined by a Western blot.

There were no significant differences between the two models for the thresholds of tactile and cold allodynia. Expression of the α2δ subunit in the ipsilateral DRG to the injury was increased as determined on a Western blot as compared to that in the contralateral or sham-operated DRG of the SMP model, but there was no difference in expression seen with the use of the SIP model. There was no difference in the expression of TRPM8 in the ipsilateral DRG to the injury and the contralateral or sham-operated DRG of either model.

Up-regulation of the α2δ subunit in injured DRG may play a role that contributes to tactile allodynia development in SMP, but not TRPM8 to cold allodynia after peripheral nerve injur
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Kweon, Tae Dong(권태동) ORCID logo https://orcid.org/0000-0002-5451-1856
Lee, Youn Woo(이윤우)
Choi, Jong Bum(최종범)
Han, Dong Woo(한동우) ORCID logo https://orcid.org/0000-0002-8757-663X
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