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구강백반증에서 상피세포와 섬유모세포의 염색체 불안정성 분석

Other Titles
 Analysis of the Chromosomal Instability in Epithelial Cells and Fibroblasts of Oral Leukoplakia 
Authors
 Jeong Hwa Kwon  ;  Du Pyo Hong  ;  Ki Yeol Kim  ;  Hyung Jun Kim  ;  Young Wook Choi  ;  Mi Heon Ryu  ;  Jin Kim 
Citation
 Korean Journal of Oral and Maxillofacial Pathology (대한구강악안면병리학회지), Vol.32(4) : 195-210, 2008 
Journal Title
 Korean Journal of Oral and Maxillofacial Pathology (대한구강악안면병리학회지) 
Issue Date
2008
Keywords
Multistep carcinogenesis ; Loss of heterozygosity(LOH) ; Microsatellite instability(MSI) ; Epithelial dysplasia
Abstract
Oral squamous cell carcinoma(OSCC) occurs through a multistep process in which accumulated genetic alterations leads to malignant transformation. Oral leukoplakia is a common premalignant lesion in oral mucosa and the incidence of cancer progression into SCC has been reported to be 0~43%. The genetic alterations of oncogenes, tumor suppressor genes and DNA repair genes occur during carcinogenesis. In order to evaluate the role of epithelial cells in the early stage of carcinogenesis, we analyzed the alterations of genetic heterogeneity in epithelial cells of oral leukoplakia samples, using Laser capture microdissection(LCM). The incidence rate of microsatellite instability(MSI) and loss of heterozygosity(LOH) were analysed from the DNA of epithelial cells from 16 leukoplakia samples using adjacent fibroblasts as a normal control. In this study, LOH was found in epithelial cells of all 16 cases of leukoplakias while MSI has been observed in 3 cases. Interestingly, the fibroblasts showed LOH and MSI in some cases, which was confirmed by DNA sequencing. Taken together, this study showed that leukoplakia has multiple genetic alterations in fibroblasts as well as in epithelial cells, suggesting that interaction between epithelial cells and fibroblasts might be involved in the early step of carcinogenesis.
Files in This Item:
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Appears in Collections:
5. Research Institutes (연구소) > Oral Cancer Research Institute (구강종양연구소) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ki Yeol(김기열) ORCID logo https://orcid.org/0000-0001-5357-1067
Kim, Jin(김진)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/108043
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