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구강백반증에서 상피세포와 섬유모세포의 염색체 불안정성 분석

DC FieldValueLanguage
dc.contributor.author김기열-
dc.contributor.author김진-
dc.contributor.author김형준-
dc.date.accessioned2015-05-19T17:23:02Z-
dc.date.available2015-05-19T17:23:02Z-
dc.date.issued2008-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/108043-
dc.description.abstractOral squamous cell carcinoma(OSCC) occurs through a multistep process in which accumulated genetic alterations leads to malignant transformation. Oral leukoplakia is a common premalignant lesion in oral mucosa and the incidence of cancer progression into SCC has been reported to be 0~43%. The genetic alterations of oncogenes, tumor suppressor genes and DNA repair genes occur during carcinogenesis. In order to evaluate the role of epithelial cells in the early stage of carcinogenesis, we analyzed the alterations of genetic heterogeneity in epithelial cells of oral leukoplakia samples, using Laser capture microdissection(LCM). The incidence rate of microsatellite instability(MSI) and loss of heterozygosity(LOH) were analysed from the DNA of epithelial cells from 16 leukoplakia samples using adjacent fibroblasts as a normal control. In this study, LOH was found in epithelial cells of all 16 cases of leukoplakias while MSI has been observed in 3 cases. Interestingly, the fibroblasts showed LOH and MSI in some cases, which was confirmed by DNA sequencing. Taken together, this study showed that leukoplakia has multiple genetic alterations in fibroblasts as well as in epithelial cells, suggesting that interaction between epithelial cells and fibroblasts might be involved in the early step of carcinogenesis.-
dc.description.statementOfResponsibilityopen-
dc.format.extent195~210-
dc.relation.isPartOfKorean Journal of Oral and Maxillofacial Pathology (대한구강악안면병리학회지)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.title구강백반증에서 상피세포와 섬유모세포의 염색체 불안정성 분석-
dc.title.alternativeAnalysis of the Chromosomal Instability in Epithelial Cells and Fibroblasts of Oral Leukoplakia-
dc.typeArticle-
dc.contributor.collegeResearcher Institutes (부설 연구소)-
dc.contributor.departmentOral Cancer Research Institute (구강종양연구소)-
dc.contributor.googleauthorJeong Hwa Kwon-
dc.contributor.googleauthorDu Pyo Hong-
dc.contributor.googleauthorKi Yeol Kim-
dc.contributor.googleauthorHyung Jun Kim-
dc.contributor.googleauthorYoung Wook Choi-
dc.contributor.googleauthorMi Heon Ryu-
dc.contributor.googleauthorJin Kim-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00337-
dc.contributor.localIdA01009-
dc.relation.journalcodeJ02084-
dc.identifier.pmidMultistep carcinogenesis ; Loss of heterozygosity(LOH) ; Microsatellite instability(MSI) ; Epithelial dysplasia-
dc.subject.keywordMultistep carcinogenesis-
dc.subject.keywordLoss of heterozygosity(LOH)-
dc.subject.keywordMicrosatellite instability(MSI)-
dc.subject.keywordEpithelial dysplasia-
dc.contributor.alternativeNameKim, Ki Yeol-
dc.contributor.alternativeNameKim, Jin-
dc.contributor.alternativeNameKim, Hyung Jun-
dc.contributor.affiliatedAuthorKim, Ki Yeol-
dc.contributor.affiliatedAuthorKim, Jin-
dc.rights.accessRightsfree-
dc.citation.volume32-
dc.citation.number4-
dc.citation.startPage195-
dc.citation.endPage210-
dc.identifier.bibliographicCitationKorean Journal of Oral and Maxillofacial Pathology (대한구강악안면병리학회지), Vol.32(4) : 195-210, 2008-
Appears in Collections:
5. Research Institutes (연구소) > Oral Cancer Research Institute (구강종양연구소) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers

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