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Interleukin-6-572C>G polymorphism-association with inflammatory variables in Korean men with coronary artery disease

Authors
 YANGSOO JANG  ;  OH YOEN KIM  ;  YAE JUNG HYUN  ;  JEY SOOK CHAE  ;  SOO JEONG KOH  ;  YU MI HEO  ;  DONGHOON CHOI  ;  DONG-JIK SHIN  ;  KENNETH HUTTNER  ;  JONG HO LEE 
Citation
 TRANSLATIONAL RESEARCH, Vol.151(3) : 154-161, 2008 
Journal Title
 TRANSLATIONAL RESEARCH 
ISSN
 1931-5244 
Issue Date
2008
MeSH
Adult ; Asian Continental Ancestry Group/genetics ; Biomarkers/blood ; C-Reactive Protein/analysis ; Coronary Artery Disease/blood* ; Coronary Artery Disease/epidemiology ; Coronary Artery Disease/genetics* ; Fibrinogen/analysis ; Genetic Predisposition to Disease ; Genotype ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Hyperlipidemias/drug therapy ; Hyperlipidemias/epidemiology ; Hyperlipidemias/genetics ; Inflammation Mediators/blood* ; Interleukin-6/blood* ; Interleukin-6/genetics* ; Korea/epidemiology ; Lipids/blood ; Male ; Middle Aged ; Polymorphism, Single Nucleotide/genetics* ; Promoter Regions, Genetic/genetics ; Reference Values
Keywords
Adult ; Asian Continental Ancestry Group/genetics ; Biomarkers/blood ; C-Reactive Protein/analysis ; Coronary Artery Disease/blood* ; Coronary Artery Disease/epidemiology ; Coronary Artery Disease/genetics* ; Fibrinogen/analysis ; Genetic Predisposition to Disease ; Genotype ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Hyperlipidemias/drug therapy ; Hyperlipidemias/epidemiology ; Hyperlipidemias/genetics ; Inflammation Mediators/blood* ; Interleukin-6/blood* ; Interleukin-6/genetics* ; Korea/epidemiology ; Lipids/blood ; Male ; Middle Aged ; Polymorphism, Single Nucleotide/genetics* ; Promoter Regions, Genetic/genetics ; Reference Values
Abstract
Growing evidence suggests that polymorphisms at position -174 and -572 in interleukin-6 (IL-6) gene are associated with various manifestations of atherosclerosis. We investigated the genotype effects of IL-6 -174 and -572 polymorphisms on circulating levels of inflammatory markers in Korean men with coronary artery disease (CAD). CAD patients were subdivided into 2 groups; those patients treated without lipid-lowering drug (LLD) (n = 173) and those treated with LLD (n = 353). No significant differences existed between the 2 groups in age, body mass index, blood pressure, serum glucose, alcohol consumption, cigarette smoking, and the proportions of antihypertensive and antiplatelet therapies. IL-6 - 572 C>G polymorphism was only observed in this population. In CAD patients not taking LLD, the G/G genotype of the -572C>G polymorphism was associated with greater concentrations of IL-6 (C/C: 4.1 +/- 0.8 pg/mL, C/G: 3.7 +/- 0.7, G/G: 12.4 +/- 6.6; P = 0.031), C-reactive protein (CRP) (C/C: 1.9 +/- 0.4 mg/dL, C/G: 2.7 +/- 0.8, G/G: 10.1 +/- 3.9; P = 0.002), fibrinogen (C/C: 334 +/- 6 mg/dL, C/G: 345 +/- 13, G/G: 429 +/- 38; P = 0.003), and oxidized low-density lipoprotein (ox-LDL) (C/C: 59 +/- 2 mg/dL, C/G: 55 +/- 3, G/G: 71 +/- 6; P = 0.041) than those with C/C or C/G. However, in the LLD group, no difference existed in circulating levels of IL-6, CRP, fibrinogen, and ox-LDL across the genotype after adjustment of age. This study suggests that circulating levels of IL-6 and its related proteins such as CRP and fibrinogen are associated with genotype at a promoter polymorphism (-572C>G) of the IL-6 gene in Korean men with CAD not taking LLD. LLD, mostly statin in this study, might reduce the exaggeration of G/G genotype-raising effect on inflammatory markers.
Full Text
http://www.sciencedirect.com/science/article/pii/S1931524407003313
DOI
10.1016/j.trsl.2007.11.004
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Choi, Dong Hoon(최동훈) ORCID logo https://orcid.org/0000-0002-2009-9760
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/108009
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