Cited 27 times in
Interleukin-6-572C>G polymorphism-association with inflammatory variables in Korean men with coronary artery disease
DC Field | Value | Language |
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dc.contributor.author | 최동훈 | - |
dc.contributor.author | 장양수 | - |
dc.date.accessioned | 2015-05-19T17:21:58Z | - |
dc.date.available | 2015-05-19T17:21:58Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 1931-5244 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/108009 | - |
dc.description.abstract | Growing evidence suggests that polymorphisms at position -174 and -572 in interleukin-6 (IL-6) gene are associated with various manifestations of atherosclerosis. We investigated the genotype effects of IL-6 -174 and -572 polymorphisms on circulating levels of inflammatory markers in Korean men with coronary artery disease (CAD). CAD patients were subdivided into 2 groups; those patients treated without lipid-lowering drug (LLD) (n = 173) and those treated with LLD (n = 353). No significant differences existed between the 2 groups in age, body mass index, blood pressure, serum glucose, alcohol consumption, cigarette smoking, and the proportions of antihypertensive and antiplatelet therapies. IL-6 - 572 C>G polymorphism was only observed in this population. In CAD patients not taking LLD, the G/G genotype of the -572C>G polymorphism was associated with greater concentrations of IL-6 (C/C: 4.1 +/- 0.8 pg/mL, C/G: 3.7 +/- 0.7, G/G: 12.4 +/- 6.6; P = 0.031), C-reactive protein (CRP) (C/C: 1.9 +/- 0.4 mg/dL, C/G: 2.7 +/- 0.8, G/G: 10.1 +/- 3.9; P = 0.002), fibrinogen (C/C: 334 +/- 6 mg/dL, C/G: 345 +/- 13, G/G: 429 +/- 38; P = 0.003), and oxidized low-density lipoprotein (ox-LDL) (C/C: 59 +/- 2 mg/dL, C/G: 55 +/- 3, G/G: 71 +/- 6; P = 0.041) than those with C/C or C/G. However, in the LLD group, no difference existed in circulating levels of IL-6, CRP, fibrinogen, and ox-LDL across the genotype after adjustment of age. This study suggests that circulating levels of IL-6 and its related proteins such as CRP and fibrinogen are associated with genotype at a promoter polymorphism (-572C>G) of the IL-6 gene in Korean men with CAD not taking LLD. LLD, mostly statin in this study, might reduce the exaggeration of G/G genotype-raising effect on inflammatory markers. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 154~161 | - |
dc.relation.isPartOf | TRANSLATIONAL RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Asian Continental Ancestry Group/genetics | - |
dc.subject.MESH | Biomarkers/blood | - |
dc.subject.MESH | C-Reactive Protein/analysis | - |
dc.subject.MESH | Coronary Artery Disease/blood* | - |
dc.subject.MESH | Coronary Artery Disease/epidemiology | - |
dc.subject.MESH | Coronary Artery Disease/genetics* | - |
dc.subject.MESH | Fibrinogen/analysis | - |
dc.subject.MESH | Genetic Predisposition to Disease | - |
dc.subject.MESH | Genotype | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use | - |
dc.subject.MESH | Hyperlipidemias/drug therapy | - |
dc.subject.MESH | Hyperlipidemias/epidemiology | - |
dc.subject.MESH | Hyperlipidemias/genetics | - |
dc.subject.MESH | Inflammation Mediators/blood* | - |
dc.subject.MESH | Interleukin-6/blood* | - |
dc.subject.MESH | Interleukin-6/genetics* | - |
dc.subject.MESH | Korea/epidemiology | - |
dc.subject.MESH | Lipids/blood | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Polymorphism, Single Nucleotide/genetics* | - |
dc.subject.MESH | Promoter Regions, Genetic/genetics | - |
dc.subject.MESH | Reference Values | - |
dc.title | Interleukin-6-572C>G polymorphism-association with inflammatory variables in Korean men with coronary artery disease | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | YANGSOO JANG | - |
dc.contributor.googleauthor | OH YOEN KIM | - |
dc.contributor.googleauthor | YAE JUNG HYUN | - |
dc.contributor.googleauthor | JEY SOOK CHAE | - |
dc.contributor.googleauthor | SOO JEONG KOH | - |
dc.contributor.googleauthor | YU MI HEO | - |
dc.contributor.googleauthor | DONGHOON CHOI | - |
dc.contributor.googleauthor | DONG-JIK SHIN | - |
dc.contributor.googleauthor | KENNETH HUTTNER | - |
dc.contributor.googleauthor | JONG HO LEE | - |
dc.identifier.doi | 10.1016/j.trsl.2007.11.004 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A04053 | - |
dc.contributor.localId | A03448 | - |
dc.relation.journalcode | J03229 | - |
dc.identifier.eissn | 1878-1810 | - |
dc.identifier.pmid | 18279814 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S1931524407003313 | - |
dc.subject.keyword | Adult | - |
dc.subject.keyword | Asian Continental Ancestry Group/genetics | - |
dc.subject.keyword | Biomarkers/blood | - |
dc.subject.keyword | C-Reactive Protein/analysis | - |
dc.subject.keyword | Coronary Artery Disease/blood* | - |
dc.subject.keyword | Coronary Artery Disease/epidemiology | - |
dc.subject.keyword | Coronary Artery Disease/genetics* | - |
dc.subject.keyword | Fibrinogen/analysis | - |
dc.subject.keyword | Genetic Predisposition to Disease | - |
dc.subject.keyword | Genotype | - |
dc.subject.keyword | Humans | - |
dc.subject.keyword | Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use | - |
dc.subject.keyword | Hyperlipidemias/drug therapy | - |
dc.subject.keyword | Hyperlipidemias/epidemiology | - |
dc.subject.keyword | Hyperlipidemias/genetics | - |
dc.subject.keyword | Inflammation Mediators/blood* | - |
dc.subject.keyword | Interleukin-6/blood* | - |
dc.subject.keyword | Interleukin-6/genetics* | - |
dc.subject.keyword | Korea/epidemiology | - |
dc.subject.keyword | Lipids/blood | - |
dc.subject.keyword | Male | - |
dc.subject.keyword | Middle Aged | - |
dc.subject.keyword | Polymorphism, Single Nucleotide/genetics* | - |
dc.subject.keyword | Promoter Regions, Genetic/genetics | - |
dc.subject.keyword | Reference Values | - |
dc.contributor.alternativeName | Choi, Dong Hoon | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.affiliatedAuthor | Choi, Dong Hoon | - |
dc.contributor.affiliatedAuthor | Jang, Yang Soo | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 151 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 154 | - |
dc.citation.endPage | 161 | - |
dc.identifier.bibliographicCitation | TRANSLATIONAL RESEARCH, Vol.151(3) : 154-161, 2008 | - |
dc.identifier.rimsid | 50061 | - |
dc.type.rims | ART | - |
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