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Impact of caveolin-1 expression on the prognosis of transitional cell carcinoma of the upper urinary tract

Authors
 Dae Sung Cho  ;  Hyunee Yim  ;  Kang Su Cho  ;  Sung Joon Hong  ;  Nam Hoon Cho  ;  Sun Il Kim  ;  Hyun Soo Ahn  ;  Se Joong Kim 
Citation
 Journal of Korean Medical Science, Vol.23(2) : 296-301, 2008 
Journal Title
 Journal of Korean Medical Science 
ISSN
 1011-8934 
Issue Date
2008
MeSH
Adult ; Aged ; Aged, 80 and over ; Carcinoma, Transitional Cell/diagnosis* ; Carcinoma, Transitional Cell/metabolism* ; Caveolin 1/biosynthesis* ; Disease Progression ; Disease-Free Survival ; Female ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic* ; Humans ; Male ; Middle Aged ; Prognosis ; Urologic Neoplasms/diagnosis* ; Urologic Neoplasms/metabolism*
Keywords
Caveolin 1 ; Prognosis ; Carcinoma ; Transitional Cell ; Upper Urinary Tract
Abstract
This study aimed to investigate the relationship of caveolin-1 expression with prognosis in patients with transitional cell carcinoma of the upper urinary tract (TCCUUT). Formalin-fixed, paraffin-embedded tissue sections of TCC-UUT from 98 patients, who had undergone radical nephroureterectomy, were stained immunohistochemically using antibodies against caveolin-1. The expression pattern of caveolin- 1 was compared with the clinicopathological variables. The caveolin-1 expression was significantly correlated with T stage (p<0.001) and grade (p=0.036). The survival rate of patients with caveolin-1 positive tumors was significantly lower than that of patients with caveolin-1 negative tumors (p<0.0001). The univariate analyses identified T stage, grade, and caveolin-1 expression as significant prognostic factors for cancer-specific survival, whereas the multivariate analyses indicated that T stage and caveolin-1 expression were independent prognostic factors. These results show that the increased expression of caveolin-1 is associated with tumor progression and poor prognosis in TCC-UUT, suggesting that caveolin-1 may play an important role in the progression of TCC-UUT
Files in This Item:
T200801664.pdf Download
DOI
10.3346/jkms.2008.23.2.296
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Cho, Kang Su(조강수) ORCID logo https://orcid.org/0000-0002-3500-8833
Cho, Nam Hoon(조남훈) ORCID logo https://orcid.org/0000-0002-0045-6441
Hong, Sung Joon(홍성준) ORCID logo https://orcid.org/0000-0001-9869-065X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/108006
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