Cited 16 times in
Impact of caveolin-1 expression on the prognosis of transitional cell carcinoma of the upper urinary tract
DC Field | Value | Language |
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dc.contributor.author | 조남훈 | - |
dc.contributor.author | 홍성준 | - |
dc.contributor.author | 조강수 | - |
dc.date.accessioned | 2015-05-19T17:21:52Z | - |
dc.date.available | 2015-05-19T17:21:52Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/108006 | - |
dc.description.abstract | This study aimed to investigate the relationship of caveolin-1 expression with prognosis in patients with transitional cell carcinoma of the upper urinary tract (TCCUUT). Formalin-fixed, paraffin-embedded tissue sections of TCC-UUT from 98 patients, who had undergone radical nephroureterectomy, were stained immunohistochemically using antibodies against caveolin-1. The expression pattern of caveolin- 1 was compared with the clinicopathological variables. The caveolin-1 expression was significantly correlated with T stage (p<0.001) and grade (p=0.036). The survival rate of patients with caveolin-1 positive tumors was significantly lower than that of patients with caveolin-1 negative tumors (p<0.0001). The univariate analyses identified T stage, grade, and caveolin-1 expression as significant prognostic factors for cancer-specific survival, whereas the multivariate analyses indicated that T stage and caveolin-1 expression were independent prognostic factors. These results show that the increased expression of caveolin-1 is associated with tumor progression and poor prognosis in TCC-UUT, suggesting that caveolin-1 may play an important role in the progression of TCC-UUT | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.relation.isPartOf | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Carcinoma, Transitional Cell/diagnosis* | - |
dc.subject.MESH | Carcinoma, Transitional Cell/metabolism* | - |
dc.subject.MESH | Caveolin 1/biosynthesis* | - |
dc.subject.MESH | Disease Progression | - |
dc.subject.MESH | Disease-Free Survival | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gene Expression Profiling | - |
dc.subject.MESH | Gene Expression Regulation, Neoplastic* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Urologic Neoplasms/diagnosis* | - |
dc.subject.MESH | Urologic Neoplasms/metabolism* | - |
dc.title | Impact of caveolin-1 expression on the prognosis of transitional cell carcinoma of the upper urinary tract | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | Dae Sung Cho | - |
dc.contributor.googleauthor | Hyunee Yim | - |
dc.contributor.googleauthor | Kang Su Cho | - |
dc.contributor.googleauthor | Sung Joon Hong | - |
dc.contributor.googleauthor | Nam Hoon Cho | - |
dc.contributor.googleauthor | Sun Il Kim | - |
dc.contributor.googleauthor | Hyun Soo Ahn | - |
dc.contributor.googleauthor | Se Joong Kim | - |
dc.identifier.doi | 10.3346/jkms.2008.23.2.296 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03812 | - |
dc.contributor.localId | A04402 | - |
dc.relation.journalcode | J01517 | - |
dc.identifier.eissn | 1598-6357 | - |
dc.identifier.pmid | 18437015 | - |
dc.subject.keyword | Caveolin 1 | - |
dc.subject.keyword | Prognosis | - |
dc.subject.keyword | Carcinoma | - |
dc.subject.keyword | Transitional Cell | - |
dc.subject.keyword | Upper Urinary Tract | - |
dc.contributor.alternativeName | Cho, Nam Hoon | - |
dc.contributor.alternativeName | Hong, Sung Joon | - |
dc.contributor.affiliatedAuthor | Cho, Nam Hoon | - |
dc.contributor.affiliatedAuthor | Hong, Sung Joon | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 23 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 296 | - |
dc.citation.endPage | 301 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.23(2) : 296-301, 2008 | - |
dc.identifier.rimsid | 50059 | - |
dc.type.rims | ART | - |
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