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Clinical efficacy of zonisamide in Lennox-Gastaut syndrome: Korean multicentric experience

Authors
 Su Jeong You  ;  Hoon-Chul Kang  ;  Heung Dong Kim  ;  Hyun Sug Lee  ;  Tae-Sung Ko 
Citation
 BRAIN & DEVELOPMENT, Vol.30(4) : 287-290, 2008 
Journal Title
 BRAIN & DEVELOPMENT 
ISSN
 0387-7604 
Issue Date
2008
MeSH
Anticonvulsants/administration & dosage* ; Anticonvulsants/adverse effects ; Child ; Child, Preschool ; Epilepsy/drug therapy* ; Female ; Follow-Up Studies ; Humans ; Infant ; Isoxazoles/administration & dosage* ; Isoxazoles/adverse effects ; Korea ; Male ; Retrospective Studies ; Treatment Outcome ; Zonisamide
Keywords
Zonisamide (ZNS) ; Lennox–Gastaut syndrome (LGS)
Abstract
PURPOSE: To evaluate the efficacy and safety of zonisamide (ZNS) as long-term adjunctive therapy in children with Lennox-Gastaut syndrome (LGS). METHOD: We evaluated the seizure frequency, cognitive outcomes, and side effects of 62 LGS patients maintained on ZNS for at least 12 months in three tertiary centers. RESULTS: Of the 62 LGS patients maintained on ZNS, 3 (4.8%) had 100% seizure control; 14 (22.6%) had >75% to <100% reduction in seizure frequency; 15 (24.2%) had >50% to <75% reduction in seizure frequency; 6 (9.7%) had >0% to <50% reduction in seizure frequency, and 24 (38.7%) had no seizure reduction. Seizure outcomes were not related to seizure types or etiologies. Adverse events included somnolence and anorexia, but all were transient and successfully managed by careful follow-up. CONCLUSION: Our results indicate that adjunctive treatment with ZNS is safe and effective in pediatric LGS patients.
Full Text
http://www.sciencedirect.com/science/article/pii/S038776040700229X
DOI
10.1016/j.braindev.2007.09.004
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Heung Dong(김흥동) ORCID logo https://orcid.org/0000-0002-8031-7336
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/107930
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