Cited 38 times in
Clinical efficacy of zonisamide in Lennox-Gastaut syndrome: Korean multicentric experience
DC Field | Value | Language |
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dc.contributor.author | 김흥동 | - |
dc.date.accessioned | 2015-05-19T17:19:28Z | - |
dc.date.available | 2015-05-19T17:19:28Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0387-7604 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/107930 | - |
dc.description.abstract | PURPOSE: To evaluate the efficacy and safety of zonisamide (ZNS) as long-term adjunctive therapy in children with Lennox-Gastaut syndrome (LGS). METHOD: We evaluated the seizure frequency, cognitive outcomes, and side effects of 62 LGS patients maintained on ZNS for at least 12 months in three tertiary centers. RESULTS: Of the 62 LGS patients maintained on ZNS, 3 (4.8%) had 100% seizure control; 14 (22.6%) had >75% to <100% reduction in seizure frequency; 15 (24.2%) had >50% to <75% reduction in seizure frequency; 6 (9.7%) had >0% to <50% reduction in seizure frequency, and 24 (38.7%) had no seizure reduction. Seizure outcomes were not related to seizure types or etiologies. Adverse events included somnolence and anorexia, but all were transient and successfully managed by careful follow-up. CONCLUSION: Our results indicate that adjunctive treatment with ZNS is safe and effective in pediatric LGS patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 287~290 | - |
dc.relation.isPartOf | BRAIN & DEVELOPMENT | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Anticonvulsants/administration & dosage* | - |
dc.subject.MESH | Anticonvulsants/adverse effects | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Child, Preschool | - |
dc.subject.MESH | Epilepsy/drug therapy* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Infant | - |
dc.subject.MESH | Isoxazoles/administration & dosage* | - |
dc.subject.MESH | Isoxazoles/adverse effects | - |
dc.subject.MESH | Korea | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Treatment Outcome | - |
dc.subject.MESH | Zonisamide | - |
dc.title | Clinical efficacy of zonisamide in Lennox-Gastaut syndrome: Korean multicentric experience | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학) | - |
dc.contributor.googleauthor | Su Jeong You | - |
dc.contributor.googleauthor | Hoon-Chul Kang | - |
dc.contributor.googleauthor | Heung Dong Kim | - |
dc.contributor.googleauthor | Hyun Sug Lee | - |
dc.contributor.googleauthor | Tae-Sung Ko | - |
dc.identifier.doi | 10.1016/j.braindev.2007.09.004 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01208 | - |
dc.relation.journalcode | J00386 | - |
dc.identifier.eissn | 1872-7131 | - |
dc.identifier.pmid | 17959327 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S038776040700229X | - |
dc.subject.keyword | Zonisamide (ZNS) | - |
dc.subject.keyword | Lennox–Gastaut syndrome (LGS) | - |
dc.contributor.alternativeName | Kim, Heung Dong | - |
dc.contributor.affiliatedAuthor | Kim, Heung Dong | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 30 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 287 | - |
dc.citation.endPage | 290 | - |
dc.identifier.bibliographicCitation | BRAIN & DEVELOPMENT, Vol.30(4) : 287-290, 2008 | - |
dc.identifier.rimsid | 34787 | - |
dc.type.rims | ART | - |
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