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Clinical efficacy of zonisamide in Lennox-Gastaut syndrome: Korean multicentric experience

DC Field Value Language
dc.contributor.author김흥동-
dc.date.accessioned2015-05-19T17:19:28Z-
dc.date.available2015-05-19T17:19:28Z-
dc.date.issued2008-
dc.identifier.issn0387-7604-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/107930-
dc.description.abstractPURPOSE: To evaluate the efficacy and safety of zonisamide (ZNS) as long-term adjunctive therapy in children with Lennox-Gastaut syndrome (LGS). METHOD: We evaluated the seizure frequency, cognitive outcomes, and side effects of 62 LGS patients maintained on ZNS for at least 12 months in three tertiary centers. RESULTS: Of the 62 LGS patients maintained on ZNS, 3 (4.8%) had 100% seizure control; 14 (22.6%) had >75% to <100% reduction in seizure frequency; 15 (24.2%) had >50% to <75% reduction in seizure frequency; 6 (9.7%) had >0% to <50% reduction in seizure frequency, and 24 (38.7%) had no seizure reduction. Seizure outcomes were not related to seizure types or etiologies. Adverse events included somnolence and anorexia, but all were transient and successfully managed by careful follow-up. CONCLUSION: Our results indicate that adjunctive treatment with ZNS is safe and effective in pediatric LGS patients.-
dc.description.statementOfResponsibilityopen-
dc.format.extent287~290-
dc.relation.isPartOfBRAIN & DEVELOPMENT-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnticonvulsants/administration & dosage*-
dc.subject.MESHAnticonvulsants/adverse effects-
dc.subject.MESHChild-
dc.subject.MESHChild, Preschool-
dc.subject.MESHEpilepsy/drug therapy*-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHumans-
dc.subject.MESHInfant-
dc.subject.MESHIsoxazoles/administration & dosage*-
dc.subject.MESHIsoxazoles/adverse effects-
dc.subject.MESHKorea-
dc.subject.MESHMale-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHZonisamide-
dc.titleClinical efficacy of zonisamide in Lennox-Gastaut syndrome: Korean multicentric experience-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아과학)-
dc.contributor.googleauthorSu Jeong You-
dc.contributor.googleauthorHoon-Chul Kang-
dc.contributor.googleauthorHeung Dong Kim-
dc.contributor.googleauthorHyun Sug Lee-
dc.contributor.googleauthorTae-Sung Ko-
dc.identifier.doi10.1016/j.braindev.2007.09.004-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01208-
dc.relation.journalcodeJ00386-
dc.identifier.eissn1872-7131-
dc.identifier.pmid17959327-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S038776040700229X-
dc.subject.keywordZonisamide (ZNS)-
dc.subject.keywordLennox–Gastaut syndrome (LGS)-
dc.contributor.alternativeNameKim, Heung Dong-
dc.contributor.affiliatedAuthorKim, Heung Dong-
dc.rights.accessRightsnot free-
dc.citation.volume30-
dc.citation.number4-
dc.citation.startPage287-
dc.citation.endPage290-
dc.identifier.bibliographicCitationBRAIN & DEVELOPMENT, Vol.30(4) : 287-290, 2008-
dc.identifier.rimsid34787-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers

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