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Association between polymorphisms in SLC30A8, HHEX, CDKN2A/B, IGF2BP2, FTO, WFS1, CDKAL1, KCNQ1 and type 2 diabetes in the Korean population

Authors
 Yong-Ho Lee  ;  Eun Seok Kang  ;  So Hun Kim  ;  Seung Jin Han  ;  Chul Hoon Kim  ;  Hyeong Jin Kim  ;  Chul Woo Ahn  ;  Bong Soo Cha  ;  Moonsuk Nam  ;  Chung Mo Nam  ;  Hyun Chul Lee 
Citation
 JOURNAL OF HUMAN GENETICS, Vol.53(11-12) : 991-998, 2008 
Journal Title
 JOURNAL OF HUMAN GENETICS 
ISSN
 1434-5161 
Issue Date
2008
MeSH
Alpha-Ketoglutarate-Dependent Dioxygenase FTO ; Blood Glucose/metabolism ; Body Mass Index ; Case-Control Studies ; Cation Transport Proteins/genetics ; Cyclin-Dependent Kinase 5/genetics ; Cyclin-Dependent Kinase Inhibitor p15/genetics ; Cyclin-Dependent Kinase Inhibitor p16/genetics ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/genetics* ; Female ; Genetic Markers/genetics* ; Genetic Predisposition to Disease ; Genome, Human ; Genome-Wide Association Study ; Genotype ; Homeodomain Proteins/genetics ; Humans ; KCNQ1 Potassium Channel/genetics ; Korea/epidemiology ; Male ; Membrane Proteins/genetics ; Middle Aged ; Polymorphism, Single Nucleotide/genetics* ; Proteins/genetics ; RNA-Binding Proteins/genetics ; Transcription Factors/genetics ; Zinc Transporter 8 ; tRNA Methyltransferases
Keywords
Type 2 diabetes ; SLC30A8 ; HHEX ; CDKN2A/B ; CDKAL1 ; KCNQ1 ; SNP ; Genetic association
Abstract
According to recent genome-wide association studies, a number of single nucleotide polymorphisms (SNPs) are reported to be associated with type 2 diabetes mellitus (T2DM). The aim of the present study was to investigate the association among the polymorphisms of SLC30A8, HHEX, CDKN2A/B, IGF2BP2, FTO, WFS1, CDKAL1 and KCNQ1 and the risk of T2DM in the Korean population. This study was based on a multicenter case-control study, including 908 patients with T2DM and 502 non-diabetic controls. We genotyped rs13266634, rs1111875, rs10811661, rs4402960, rs8050136, rs734312, rs7754840 and rs2237892 and measured the body weight, body mass index and fasting plasma glucose in all patients and controls. The strongest association was found in a variant of CDKAL1 [rs7754840, odds ratio (OR) = 1.77, 95% CI = 1.50-2.10, p = 5.0 x 10(-11)]. The G allele of rs1111875 (OR = 1.43, 95% CI = 1.18-1.72, p = 1.8 x 10(-4)) in HHEX), the T allele of rs10811661 (OR = 1.47, 95% CI = 1.23-1.75, p = 2.1 x 10(-5)) in CDKN2A/B) and the C allele of rs2237892 (OR = 1.31, 95% CI = 1.10-1.56, p = 0.003) in KCNQ1 showed significant associations with T2DM. Rs13266634 (OR = 1.19, 95% CI = 1.00-1.42, p = 0.045) in SLC30A8 showed a nominal association with the risk of T2DM, whereas SNPs in IGF2BP2, FTO and WFS1 were not associated. In conclusion, we have shown that SNPs in HHEX, CDKN2A/B, CDKAL1, KCNQ1 and SLC30A8 confer a risk of T2DM in the Korean population.
Full Text
http://www.nature.com/jhg/journal/v53/n11/full/jhg2008127a.html
DOI
10.1007/s10038-008-0341-8
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
Yonsei Authors
Kang, Eun Seok(강은석) ORCID logo https://orcid.org/0000-0002-0364-4675
Kim, Chul Hoon(김철훈) ORCID logo https://orcid.org/0000-0002-7360-429X
Nam, Jung Mo(남정모) ORCID logo https://orcid.org/0000-0003-0985-0928
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Lee, Yong Ho(이용호) ORCID logo https://orcid.org/0000-0002-6219-4942
Lee, Hyun Chul(이현철)
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/107895
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