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Low prevalence of drug-resistant HIV-1 in patients newly diagnosed with early stage of HIV infection in Korea.

Authors
 Chang Oh Kim  ;  Bum Sik Chin  ;  Sang Hoon Han  ;  Han Sung Lee  ;  Su Jin Jeong  ;  Hee Kyung Choi  ;  Jun Yong Choi  ;  Young Goo Song  ;  Joo Shil Lee  ;  June Myung Kim 
Citation
 Tohoku Journal of Experimental Medicine, Vol.216(3) : 259-265, 2008 
Journal Title
 Tohoku Journal of Experimental Medicine 
ISSN
 0040-8727 
Issue Date
2008
MeSH
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Demography ; Drug Resistance, Viral* ; Female ; HIV Infections/diagnosis* ; HIV Infections/epidemiology ; HIV Infections/genetics ; HIV Infections/virology* ; HIV-1/physiology* ; Humans ; Korea/epidemiology ; Male ; Middle Aged ; Mutation/genetics ; Prevalence
Keywords
anti-retroviral drugs ; genotypic drug resistance ; HIV ; HIV infection ; resistance mutation
Abstract
There is a concern that the widespread use of antiretroviral drugs to treat HIV infections may result in the increased transmission of a drug-resistant virus. Drug resistance testing before initiating treatment among newly diagnosed HIV patients is helpful in the design of initial regimens. Although HIV infected patients have been increasing in Korea, the transmission rate of drug-resistant HIV is unknown. The aim of this study was to determine the prevalence of antiretroviral drug resistance-associated mutations in patients newly diagnosed as early stage of HIV infection in Korea. We defined patients with early HIV infections as those with confirmed diagnoses who had an indeterminate Western blot. We performed genotypic resistance testing in 66 HIV-1 subjects at an early HIV infection stage who were identified between March 2002 and June 2005. Two of the 66 subjects with early HIV infections showed major mutations associated with resistance. Major mutations by themselves reduce susceptibility to one or more drugs and occur commonly during virological failure. Minor mutations have little or no effect on susceptibility and occur only after other drug-resistance mutations. The resistant mutation of reverse-transcriptase gene was found at E44D, and the major resistant mutation of protease gene was found at M46L. Minor protease resistance mutations were seen in 52 cases. Genetic subtype analysis revealed that all subjects were infected with HIV-1 subtype B. In conclusion, the prevalence of drug-resistant HIV-1 in patients newly diagnosed with HIV in its early infection stage is not high in Korea.
Files in This Item:
T200801473.pdf Download
DOI
10.1620/tjem.216.259
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chang Oh(김창오) ORCID logo https://orcid.org/0000-0002-0773-5443
Song, Young Goo(송영구) ORCID logo https://orcid.org/0000-0002-0733-4156
Lee, Han Sung(이한성)
Jeong, Su Jin(정수진) ORCID logo https://orcid.org/0000-0003-4025-4542
Chin, Bum Sik(진범식)
Choi, Jun Yong(최준용) ORCID logo https://orcid.org/0000-0002-2775-3315
Choi, Hee Kyoung(최희경)
Han, Sang Hoon(한상훈) ORCID logo https://orcid.org/0000-0002-4278-5198
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/107787
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