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Bone metabolism in postmenopausal women with lumbar spinal stenosis: analysis of bone mineral density and bone turnover markers

Authors
 Ho-Joong Kim  ;  Hwan-Mo Lee  ;  Hak-Sun Kim  ;  Jin-Oh Park  ;  Eun-Su Moon  ;  Hoon Park  ;  Si-Young Park  ;  Seong-Hwan Moon 
Citation
 SPINE, Vol.33(22) : 2435-2439, 2008 
Journal Title
 SPINE 
ISSN
 0362-2436 
Issue Date
2008
MeSH
Aged ; Alkaline Phosphatase/urine ; Bone Density* ; Bone Remodeling* ; Case-Control Studies ; Collagen/urine ; Cross-Sectional Studies ; Exercise Tolerance ; Female ; Humans ; Intermittent Claudication/physiopathology ; Lumbar Vertebrae* ; Middle Aged ; Mobility Limitation ; Osteoarthritis, Knee/physiopathology ; Postmenopause* ; Spinal Stenosis/metabolism ; Spinal Stenosis/physiopathology* ; Vitamin D Deficiency/physiopathology ; Walking
Keywords
spinal stenosis ; bone turnover rate ; bone turnover marker ; bone mineral density
Abstract
STUDY DESIGN: A cross-sectional study. OBJECTIVE: To investigate bone mineral density (BMD) and the change of bone turnover rate in postmenopausal women with lumbar spinal stenosis (LSS). SUMMARY OF BACKGROUND DATA: Symptomatic LSS prevents elderly patients from performing daily activities because of back pain and neurogenic claudication. Walking intolerance due to neurologic claudication might have a negative effect on bone metabolism and BMD. However, there has been no study on the relationship between LSS and bone metabolism, especially on bone turnover rate. METHODS: Sixty-seven patients were in the LSS group. As a control group, 67 age- and weight-matched subjects were selected. In both groups, BMD, bone turnover markers, vitamin D, severity of knee osteoarthritis, and demographic data were obtained. In the LSS group, walking distance without rest was also recorded. BMD, bone turnover markers, vitamin D, and severity of knee osteoarthritis were compared between the two groups. In the LSS group, the correlation between walking intolerance and bone turnover markers was also analyzed. RESULTS: In the LSS group, urinary N-terminal telopeptide of type I collagen (u-NTx) and alkaline phosphatase were significantly elevated when compared with those of the control group (P < 0.05). However, BMD was significantly low in the control group in all of the measured sites (P < 0.05). In the LSS group, neither bone markers nor BMD were correlated with the extent of walking difficulty. CONCLUSION: Our study highlights the fact that limited physical activity results in high bone turnover rate in patients with LSS
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00007632-200810150-00012&LSLINK=80&D=ovft
DOI
10.1097/BRS.0b013e3181829fca
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hak Sun(김학선) ORCID logo https://orcid.org/0000-0002-8330-4688
Kim, Ho Joong(김호중)
Moon, Seong Hwan(문성환)
Moon, Eun Su(문은수)
Park, Jin Oh(박진오)
Lee, Hwan Mo(이환모) ORCID logo https://orcid.org/0000-0002-5405-3832
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/107740
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