1 150

Cited 12 times in

Increased plasma levels of heat shock protein 70 in patients with vascular mild cognitive impairment

Authors
 Kang Soo Lee  ;  Ji Hyung Chung  ;  Byung Hoon Oh  ;  Chang Hyung Hong 
Citation
 NEUROSCIENCE LETTERS, Vol.436(2) : 223-226, 2008 
Journal Title
 NEUROSCIENCE LETTERS 
ISSN
 0304-3940 
Issue Date
2008
MeSH
Aged ; Alzheimer Disease/blood ; Alzheimer Disease/complications ; Case-Control Studies ; Cognition Disorders/blood* ; Cognition Disorders/classification ; Cognition Disorders/etiology ; Female ; HSP70 Heat-Shock Proteins/blood* ; Heat-Shock Proteins/blood ; Humans ; Male
Keywords
Heat shock protein ; Mild cognitive impairment ; Vascular mild cognitive impairment ; Alzheimer's disease ; Biomarker ; Elderly
Abstract
Heat shock proteins (Hsps) have been regarded as cytoprotectants that protect brain cells from damage encountered following cerebral ischemia or during the progression of neurodegenerative diseases. In this study, we assessed the plasma Hsp70 and Hsp27 levels in not cognitively impaired (NCI) subjects and in patients with mild cognitive impairment (MCI), vascular mild cognitive impairment (VMCI), and probable Alzheimer's disease (AD). Comparison of the plasma Hsp70 and Hsp27 levels of the 4 groups revealed that only the plasma Hsp70 level of VMCI patients (14.11 ng/ml) was significantly higher than that of NCI subjects (11.32 ng/ml), MCI patients (10.16 ng/ml), and patients with probable AD (10.16 ng/ml) after adjustment of age, sex, and education (F=4.231, d.f.=3, p=0.008). Furthermore, there was no difference in plasma Hsp27 levels among the 4 groups. These findings suggest that the plasma Hsp70 level may be related to vascular factors or inflammation
Full Text
http://www.sciencedirect.com/science/article/pii/S0304394008003376
DOI
10.1016/j.neulet.2008.03.025
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Oh, Byong Hoon(오병훈)
Lee, Kang Soo(이강수)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/107689
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse