Cited 31 times in
Mechanism of azithromycin treatment on gingival overgrowth
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김현정 | - |
dc.contributor.author | 박광균 | - |
dc.contributor.author | 이창기 | - |
dc.contributor.author | 정원윤 | - |
dc.contributor.author | 조규성 | - |
dc.contributor.author | 최성호 | - |
dc.date.accessioned | 2015-05-19T17:11:15Z | - |
dc.date.available | 2015-05-19T17:11:15Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0022-0345 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/107667 | - |
dc.description.abstract | Azithromycin is effective for the remission of cyclosporine A-induced gingival overgrowth (CIGO) in persons who have undergone renal transplant. To explain its mechanism in alleviating the clinical symptoms of these individuals, we examined the effect of azithromycin on cell proliferation and collagen turnover modified by cyclosporin A in human gingival fibroblasts from healthy persons and from persons who had undergone renal transplant. Cyclosporin A-induced proliferation of renal transplant fibroblasts and normal fibroblasts was inhibited by azithromycin. Azithromycin elevated the reduced metalloproteinase (MMP)-1 and MMP-2 activities in cyclosporine A-treated renal transplant fibroblasts and normal fibroblasts. In cyclosporine A-treated renal transplant fibroblasts, azithromycin blocked the accumulation of total collagen in culture media and the increase in type I collagen mRNA level, but recovered the reduced MMP-2 mRNA level to the control. These results suggest that azithromycin may improve CIGO by blocking cyclosporine A-induced cell proliferation and collagen synthesis, and by activating MMP-2 in gingival fibroblasts of persons with cyclosporine A-induced gingival overgrowth | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1075~1079 | - |
dc.relation.isPartOf | JOURNAL OF DENTAL RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Azithromycin/pharmacology* | - |
dc.subject.MESH | Azithromycin/therapeutic use* | - |
dc.subject.MESH | Cell Proliferation/drug effects | - |
dc.subject.MESH | Cells, Cultured | - |
dc.subject.MESH | Chondrogenesis/drug effects* | - |
dc.subject.MESH | Collagen Type I/biosynthesis | - |
dc.subject.MESH | Cyclosporine/adverse effects | - |
dc.subject.MESH | Enzyme Activators/pharmacology* | - |
dc.subject.MESH | Enzyme Activators/therapeutic use* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fibroblasts/drug effects | - |
dc.subject.MESH | Fibroblasts/enzymology | - |
dc.subject.MESH | Gingival Overgrowth/chemically induced | - |
dc.subject.MESH | Gingival Overgrowth/drug therapy* | - |
dc.subject.MESH | Gingival Overgrowth/enzymology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunosuppressive Agents/adverse effects | - |
dc.subject.MESH | Kidney Transplantation | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Matrix Metalloproteinase 2/metabolism | - |
dc.subject.MESH | Middle Aged | - |
dc.title | Mechanism of azithromycin treatment on gingival overgrowth | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Periodontology (치주과학) | - |
dc.contributor.googleauthor | J.-Y. Kim | - |
dc.contributor.googleauthor | S.-H. Park | - |
dc.contributor.googleauthor | K.-S. Cho | - |
dc.contributor.googleauthor | H.-J. Kim | - |
dc.contributor.googleauthor | C.-K. Lee | - |
dc.contributor.googleauthor | K.-K. Park | - |
dc.contributor.googleauthor | S.-H. Choi | - |
dc.contributor.googleauthor | W.-Y. Chung | - |
dc.identifier.doi | 10.1177/154405910808701110 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01429 | - |
dc.contributor.localId | A03242 | - |
dc.contributor.localId | A03676 | - |
dc.contributor.localId | A03810 | - |
dc.contributor.localId | A04081 | - |
dc.contributor.localId | A01132 | - |
dc.relation.journalcode | J01367 | - |
dc.identifier.eissn | 1544-0591 | - |
dc.identifier.pmid | 18946018 | - |
dc.identifier.url | http://jdr.sagepub.com/content/87/11/1075 | - |
dc.subject.keyword | Cyclosporin A | - |
dc.subject.keyword | gingival overgrowth | - |
dc.subject.keyword | azithromycin | - |
dc.subject.keyword | matrix metalloprotease-2 | - |
dc.contributor.alternativeName | Kim, Hyun Jeong | - |
dc.contributor.alternativeName | Park, Kwang Kyun | - |
dc.contributor.alternativeName | Lee, Chang Ki | - |
dc.contributor.alternativeName | Chung, Won Yoon | - |
dc.contributor.alternativeName | Cho, Kyoo Sung | - |
dc.contributor.alternativeName | Choi, Seong Ho | - |
dc.contributor.affiliatedAuthor | Park, Kwang Kyun | - |
dc.contributor.affiliatedAuthor | Lee, Chang Ki | - |
dc.contributor.affiliatedAuthor | Chung, Won Yoon | - |
dc.contributor.affiliatedAuthor | Cho, Kyoo Sung | - |
dc.contributor.affiliatedAuthor | Choi, Seong Ho | - |
dc.contributor.affiliatedAuthor | Kim, Hyun Jeong | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 87 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1075 | - |
dc.citation.endPage | 1079 | - |
dc.identifier.bibliographicCitation | JOURNAL OF DENTAL RESEARCH, Vol.87(11) : 1075-1079, 2008 | - |
dc.identifier.rimsid | 54823 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.