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Phenotypic spectrum and clinical characteristics of apical hypertrophic cardiomyopathy: multicenter echo-Doppler study

Authors
 Eui-Young Choi  ;  Se-Joong Rim  ;  Jong-Won Ha  ;  Yong-Jin Kim  ;  Sang-Chol Lee  ;  Duk-Hyun Kang  ;  Seung Woo Park  ;  Jae-Kwan Song  ;  Dae-Won Sohn  ;  Namsik Chung 
Citation
 CARDIOLOGY, Vol.110(1) : 53-61, 2008 
Journal Title
CARDIOLOGY
ISSN
 0008-6312 
Issue Date
2008
MeSH
Age Factors ; Aged ; Analysis of Variance ; Cardiomyopathy, Hypertrophic/diagnostic imaging* ; Cardiomyopathy, Hypertrophic/genetics* ; Cardiomyopathy, Hypertrophic/physiopathology ; Echocardiography, Doppler ; Electrocardiography ; Female ; Genetic Predisposition to Disease* ; Humans ; Linear Models ; Male ; Middle Aged ; Phenotype* ; Prognosis ; Prospective Studies ; Risk Assessment ; Severity of Illness Index ; Sex Factors ; Stroke Volume
Keywords
Age Factors ; Aged ; Analysis of Variance ; Cardiomyopathy, Hypertrophic/diagnostic imaging* ; Cardiomyopathy, Hypertrophic/genetics* ; Cardiomyopathy, Hypertrophic/physiopathology ; Echocardiography, Doppler ; Electrocardiography ; Female ; Genetic Predisposition to Disease* ; Humans ; Linear Models ; Male ; Middle Aged ; Phenotype* ; Prognosis ; Prospective Studies ; Risk Assessment ; Severity of Illness Index ; Sex Factors ; Stroke Volume
Abstract
OBJECTIVES: The aim of this study was to define the phenotypic spectrum of apical hypertrophic cardiomyopathy (ApHCM) and clinical characteristics pertaining to identified subtypes.

METHODS: In 182 consecutive ApHCM patients (58.9 +/- 11.2 years; 142 men) with left ventricular ejection fraction > or =50%, we measured end-diastolic wall thickness of all 16 left ventricular segments to determine patterns of hypertrophy. Echo-Doppler parameters, electrocardiography patterns, and clinical findings were analyzed.

RESULTS: ApHCM was classified into three types as pure focal (n = 81), pure diffuse (n = 70) and mixed type (n = 31) according to patterns of hypertrophy. Incidence of atrial fibrillation (5% for pure focal vs. 11% for pure diffuse vs. 23% for mixed type, p < 0.05) and left atrial volume index (30.9 +/- 11.8, 35.7 +/- 14.8, and 41.3 +/- 15.9 ml/m(2), respectively, p < 0.001) were significantly different among subtypes. Peak systolic (6.6 +/- 1.0 vs. 6.3 +/- 1.2 vs. 5.9 +/- 1.1 cm/s, respectively, p < 0.05), diastolic (5.1 +/- 1.8 vs. 5.0 +/- 1.2 vs. 4.1 +/- 1.3 cm/s, respectively, p < 0.05) mitral annular velocity, E/E' (13.3 +/- 4.2 vs. 13.7 +/- 5.4 vs. 16.1 +/- 6.1, respectively, p < 0.05) were also significantly different.

CONCLUSIONS: ApHCM contains three morphologically distinct phenotypes and detailed subtyping is important in the prediction of development of atrial fibrillation, left atrial volume index and left ventricular longitudinal function.
Full Text
http://www.karger.com/Article/FullText/109407
DOI
10.1159/000109407
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Rim, Se Joong(임세중) ORCID logo https://orcid.org/0000-0002-7631-5581
Chung, Nam Sik(정남식)
Choi, Eui Young(최의영) ORCID logo https://orcid.org/0000-0003-3732-0190
Ha, Jong Won(하종원) ORCID logo https://orcid.org/0000-0002-8260-2958
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/107660
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