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흰쥐를 이용한 실험적 맥락막신생혈관 모델에서 유리체강내 양막 주입의 효과

Other Titles
 Effects of Intravitreal Amniotic Membrane Injection in a Rat Model of Choroidal Neovascularization 
Authors
 이종현  ;  정재림  ;  홍사민  ;  고형준 
Citation
 JOURNAL OF THE KOREAN OPHTHALMOLOGICAL SOCIETY, Vol.49(7) : 1154-1158, 2008 
Journal Title
 JOURNAL OF THE KOREAN OPHTHALMOLOGICAL SOCIETY 
ISSN
 0378-6471 
Issue Date
2008
Keywords
Amniotic membrane ; Angiogenesis ; Choroidal neovascularization
Abstract
Purpose: To evaluate the effects of an intravitreal amniotic membrane (AM) injection on a rat model of laser-induced choroidal neovascularization (CNV). Methods: Intravitreal injection of AM (12.5 μg/mL) into the left eyes and phosphate-buffered saline into the fellow eyes of 15 rats was performed immediately after laser injury. At week 2, after angiography, the rats were sacrificed, and histopathologic analysis was performed. Angiographic and histopathologic assessments of the effects of AM injection on CNV growth were compared between the two groups. Results: CNV thickness was found to have increased more in the AM treatment group (141.54±8.12 μm) than in the experimental control group (65.23±16.90 μm) (p=0.010). Conclusions: Intravitreal AM injection demonstrated histopathologic pro-angiogenic properties in a rat model of CNV
Files in This Item:
T200801314.pdf Download
DOI
10.3341/jkos.2008.49.7.1154
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Koh, Hyoung Jun(고형준) ORCID logo https://orcid.org/0000-0002-5932-8516
Chung, Jae Lim(정재림)
Hong, Sa Min(홍사민)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/107613
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