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Objective evaluation of cataract progression associated with a high dose intravitreal triamcinolone injection

Authors
 YK Chu  ;  EJ Chung  ;  OW Kwon  ;  JH Lee  ;  HJ Koh 
Citation
 Eye, Vol.22(7) : 895-899, 2008 
Journal Title
 Eye 
ISSN
 0950-222X 
Issue Date
2008
Abstract
PURPOSE: To investigate the progression of cataract after a high dose (25 mg) intravitreal triamcinolone acetonide injection in patients with macular oedema secondary to diabetes and retinal vein occlusion. METHODS: This prospective interventional case series study included 38 patients (76 eyes) with diabetic retinopathy or retinal vein occlusion diagnosed with clinical examination and fluorescein angiography. The patients were treated with 25 mg IVTA in their one eye with macular oedema and the fellow eyes served as a control. Patients were asked to return the next day and weekly for 1 month and monthly thereafter by 6 months post-operative. The progression of the cataract using photographic evaluation according to the Lens Opacities Classification System III was documented and statistical analysis was done using the Kaplan-Meier survival analysis and the log-rank test. RESULTS: Among the 38 treated eyes, there was an increase of cataract degree by 1 grade at the end of 6 months in 10 patients. The types of progressed cataract were PSC in seven patients, cortical in six patients, and nuclear sclerosis in one patient. Six months after the injections, there was a significantly higher rate of progression of PSC (P=0.023, log-rank test) and cortical opacities (P=0.011) in the treated group while the progression of nuclear cataract was not significantly different between the treated eye and the control eye. CONCLUSION: A high-dose (25 mg) intravitreal triamcinolone acetonide injection induces the progression of cortical and posterior subcapsular opacity in patients with diabetic macular oedema and retinal vein occlusion.
Full Text
http://www.nature.com/eye/journal/v22/n7/full/6702802a.html
DOI
10.1038/sj.eye.6702802
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실)
Yonsei Authors
고형준(Koh, Hyoung Jun)
권오웅(Kwon, Oh Woong)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/107611
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