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혈액투석을 시행받고 있는 말기 신부전증 환자에서 투석 방법에 따른 피부색의 변화

Other Titles
 Changes in Skin Color in Hemodialysis Patients According to Dialysis Modality 
 김찬호  ;  강신욱  ;  문성진  ;  고광일  ;  김동현  ;  김은영  ;  박정탁  ;  장태익  ;  김현욱  ;  박선영  ;  장제현  ;  김동기  ;  유태현  ;  한대석 
 Korean Journal of Nephrology, Vol.27(5) : 569-575, 2008 
Journal Title
 Korean Journal of Nephrology 
Issue Date
Dialysis ; Hyperpigmentation ; Hemodiafiltration
Purpose: Skin hyperpigmentation in end stage renal disease patients is known to be attributed to the accumulation of middle molecular weight (MMW) substances such as urochromic pigments and carotenoids. Therefore, there is a possibility that hyperpigmentation may be improved by high-flux hemodialysis (HF-HD) and online hemodiafiltration (HDF). This prospective study was undertaken to investigate the quantitative changes in skin color in HD patients according to dialysis modality. Methods: Eighty-two stable ESRD patients undergoing HD were enrolled and divided into three groups according to their dialysis modality. Melanin index and erythema index of forearm and abdomen (non-sun exposed area), and forehead (sun exposed area) were measured by narrow-band reflectance spectrophotometer at baseline and after 12 months. Results: There were no significant differences in the baseline values of melanin and erythema indices among the three groups. But the changes in forehead melanin index were significantly lower in HDF patients (-1.0±2.4%) compared to the LF-HD group (0.3±1.6%) (p<0.05), and forehead erythema index was significantly decreased in patients treated by HDF (-1.6±2.5%) relative to the low-flux hemodialysis group (-0.1±2.5%) (p<0.05). Conclusion: The changes in skin color of sun exposed area were reduced by HDF, suggesting that enhanced removal of MMW substances by convective therapy may be of advantage to skin hyper-pigmentation in ESRD patients
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Shin Wook(강신욱) ORCID logo https://orcid.org/0000-0002-5677-4756
Ko, Kwang Il(고광일)
Kim, Dong Ki(김동기)
Kim, Dong Hyun(김동현)
Kim, Chan Ho(김찬호)
Kim, Hyun Wook(김현욱) ORCID logo https://orcid.org/0000-0002-4274-7562
Park, Sun Young(박선영)
Park, Jung Tak(박정탁) ORCID logo https://orcid.org/0000-0002-2325-8982
Yoo, Tae Hyun(유태현) ORCID logo https://orcid.org/0000-0002-9183-4507
Chang, Jae Hyun(장제현)
Chang, Tae Ik(장태익)
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