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Autologous bone marrow cell transplantation combined with off-pump coronary artery bypass grafting in patients with ischemic cardiomyopathy

Authors
 Kyung-Jong Yoo  ;  Hyun-Ok Kim  ;  Young-Lan Kwak  ;  Seok-Min Kang  ;  Yang-Soo Jang  ;  Sang-Hyun Lim  ;  Ki-Chul Hwang  ;  Seung-Woo Cho  ;  Yoon-Sun Yang  ;  Ren-Ke Li  ;  Byung-Soo Kim 
Citation
 CANADIAN JOURNAL OF SURGERY, Vol.51(4) : 269-275, 2008 
Journal Title
 CANADIAN JOURNAL OF SURGERY 
ISSN
 0008-428X 
Issue Date
2008
MeSH
Aged ; Angina, Unstable/diagnosis ; Angina, Unstable/surgery* ; Bone Marrow Transplantation/methods* ; Coronary Angiography ; Coronary Artery Bypass, Off-Pump/methods* ; Electrocardiography ; Follow-Up Studies ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Time Factors ; Tomography, Emission-Computed, Single-Photon ; Transplantation, Autologous ; Treatment Outcome
Keywords
Aged ; Angina, Unstable/diagnosis ; Angina, Unstable/surgery* ; Bone Marrow Transplantation/methods* ; Coronary Angiography ; Coronary Artery Bypass, Off-Pump/methods* ; Electrocardiography ; Follow-Up Studies ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Time Factors ; Tomography, Emission-Computed, Single-Photon ; Transplantation, Autologous ; Treatment Outcome
Abstract
BACKGROUND: Clinical studies have demonstrated that intracoronary or intramyocardial transplantation of bone marrow mononuclear cells (BMMNCs) into ischemic myocardium improves cardiac function. The objective of the present study was to evaluate the safety and feasibility of intramyocardial BMMNC transplantation into nongraftable areas in combination with off-pump coronary artery bypass grafting in patients with ischemic cardiomyopathy. METHODS: Five male patients with myocardial infarction lasting for more than 1 month and with nongraftable myocardium received autologous mononuclear cell transplantation during off-pump coronary artery bypass grafting. Autologous bone marrow was aspirated from the iliac crest. BMMNCs (mean 1.6, standard error [SE] 0.3 x 10(9)) including CD34-positive cells (mean 6.8, SE 1.1 x 10(6)) and AC133-positive cells (mean 3.1, SE 1.7 x 10(6)) were injected into the nongraftable ischemic myocardium. Heart function was evaluated with the use of echocardiography, and myocardial perfusion was examined with single photon emission computed tomography technetium-99mTc sestamibi scans. RESULTS: Two months after cell transplantation, the mean ejection fraction had increased by 7.4%, SE 1.9% (p = 0.016) compared with that before cell transplantation and off-pump coronary artery bypass grafting. The increase in ejection fraction was not correlated with the number of transplanted total mononuclear cells, CD34-positive cells and AC133-positive cells. Myocardial perfusion at the cell-transplanted area increased after cell transplantation and off-pump coronary artery bypass grafting. No arrhythmia was observed. CONCLUSION: The present clinical study suggests that intramyocardial transplantation of autologous BMMNCs into the ischemic area during off-pump coronary artery bypass grafting is both feasible and safe and has beneficial effects on cardiac function
Files in This Item:
T200801298.pdf Download
DOI
18815649
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Kang, Seok Min(강석민) ORCID logo https://orcid.org/0000-0001-9856-9227
Kwak, Young Lan(곽영란) ORCID logo https://orcid.org/0000-0002-2984-9927
Kim, Hyun Ok(김현옥) ORCID logo https://orcid.org/0000-0002-4964-1963
Yoo, Kyung Jong(유경종) ORCID logo https://orcid.org/0000-0002-9858-140X
Lim, Sang Hyun(임상현)
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Hwang, Ki Chul(황기철)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/107593
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