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The role of Nox4 in oxidative stress-induced MUC5AC overexpression in human airway epithelial cells

Authors
 Hyun Jik Kim  ;  Young-Duck Park  ;  Uk Yeol Moon  ;  Jun-Hee Kim  ;  Ju Hyun Jeon  ;  Jeung-Gweon Lee  ;  Yun Soo Bae  ;  Joo-Heon Yoon 
Citation
 American Journal of Respiratory Cell and Molecular Biology, Vol.39(5) : 598-609, 2008 
Journal Title
 American Journal of Respiratory Cell and Molecular Biology 
ISSN
 1044-1549 
Issue Date
2008
MeSH
Cell Membrane/metabolism ; Cells, Cultured ; Cytoplasm/metabolism ; Enzyme Activation/drug effects ; Epithelial Cells/drug effects ; Epithelial Cells/metabolism* ; ErbB Receptors/metabolism ; Gene Expression Regulation/drug effects ; Goblet Cells/metabolism ; Humans ; Hydrogen Peroxide/pharmacology ; Ligands ; Mitogen-Activated Protein Kinase 3/metabolism ; Mucin 5AC ; Mucins/genetics ; Mucins/metabolism* ; NADPH Oxidase 4 ; NADPH Oxidases/genetics ; NADPH Oxidases/metabolism* ; Nasal Mucosa/metabolism* ; Nose/drug effects ; Oxidative Stress* ; Phosphorylation ; Reactive Oxygen Species/metabolism
Keywords
hydrogen peroxide ; MUC5AC ; epidermal growth factor receptor ; Nox4
Abstract
Mucus hypersecretion is a prominent manifestation in patients with chronic inflammatory airway diseases, and MUC5AC is a major airway mucin. It is well known that reactive oxygen species (ROS) may be involved in the pathogenesis of various inflammatory airway diseases. The purpose of this study was to identify which secreted mucin genes are induced by exogenous hydrogen peroxide and the mechanism by which these genes are up-regulated in normal human nasal epithelial (NHNE) cells. Exogenous H(2)O(2) induced the ligand-independent activation of epidermal growth factor receptors (EGFR) and the subsequent activation of ERK1 mitogen-activated protein kinase, resulting in the induction of intracellular ROS generation. Through this signal pathway, exogenous H(2)O(2) markedly induced overexpression of the MUC5AC gene alone. In addition, Nox4, a subtype of nonphagocytic NADPH oxidase, was found to play a key role in intracellular ROS generation and exogenous H(2)O(2)-induced MUC5AC gene expression in NHNE cells
Full Text
http://www.atsjournals.org/doi/abs/10.1165/rcmb.2007-0262OC
DOI
10.1165/rcmb.2007-0262OC
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터) > 1. Journal Papers
Yonsei Authors
Moon, Uk Yeol(문욱열)
Park, Young Duck(박영덕)
Yoon, Joo Heon(윤주헌)
Lee, Jeung Gweon(이정권)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/107556
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