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Non-small cell lung cancer with ipsilateral pulmonary metastases: prognosis analysis and staging assessment

Authors
 Jin Gu Lee  ;  Chang Young Lee  ;  Dae Joon Kim  ;  Kyung Young Chung  ;  In Kyu Park 
Citation
 European Journal of Cardio-Thoracic Surgery, Vol.33(3) : 480-484, 2008 
Journal Title
 European Journal of Cardio-Thoracic Surgery 
ISSN
 1010-7940 
Issue Date
2008
MeSH
Adult ; Aged ; Carcinoma, Non-Small-Cell Lung/pathology* ; Carcinoma, Non-Small-Cell Lung/secondary* ; Carcinoma, Non-Small-Cell Lung/surgery ; Disease-Free Survival ; Female ; Humans ; Lung Neoplasms/pathology ; Lung Neoplasms/secondary* ; Lung Neoplasms/surgery ; Male ; Middle Aged ; Multivariate Analysis ; Neoplasm Staging/methods* ; Retrospective Studies
Keywords
Ipsilateral pulmonary metastasis ; Non-small cell lung cancer ; Staging
Abstract
OBJECTIVE: Although designated as T4 or M1 in the current TNM classification system revised in 1997, non-small cell lung cancer with ipsilateral pulmonary metastases is treated as a locally advanced disease and reported survival rates are relatively good. We intended to analyze the prognosis of ipsilateral pulmonary metastases and validate current TNM classification system. METHODS: Data of 1213 surgically treated patients with non-small cell lung cancer from January 1990 to December 2004 were retrospectively reviewed. Overall and disease-free survival rates of patients with ipsilateral pulmonary metastases and other T stages were obtained by the Kaplan-Meier method and compared by the log rank test. Prognostic impact of ipsilateral pulmonary metastases on disease-free survival was sought by multivariate analysis. RESULTS: Among 49 patients with ipsilateral pulmonary metastases (IPM), 23 patients had metastasis in primary lobe (IPM1) and 26 had metastasis in non-primary lobe (IPM2). Five-year overall and disease-free survival rates of IPM1 and IPM2 were not significantly different (30.3% vs 30.7%, p=0.95, 21.9% vs 23.1%, p=0.78). Prognoses of IPM1 and IPM2 were not significantly different than those of T3 disease (30.1%, 26.6%). Resected T4 disease excluding IPM1 had a tendency to show the worse prognosis (16.2%, 7.5%) without significant difference with IPM1 and IPM2. In the univariate analysis of prognostic factors for disease-free survival, IPM1 and IPM2 were prognostic factors. In the multivariate analysis, IPM2 (1.554, 1.02-2.34, p=0.039) was one of independent negative prognostic factors. However, IPM1 was not an independent prognostic factor (1.31, 0.84-2.04, p=0.23). CONCLUSIONS: Regarding prognosis, prognostic strength, extent of disease and surgical treatment the current TNM classification system may be inappropriate in designation of ipsilateral pulmonary metastases and needs revision. The authors suggest that the IPM1 should be staged as T3 or designated as upstaging co-parameter of T stage as like in 1992 TNM classification and IPM2 can be staged as T4 as like in 1992 TNM classification
Full Text
http://ejcts.oxfordjournals.org/content/33/3/480.long
DOI
10.1016/j.ejcts.2007.12.005
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dae Joon(김대준)
Park, In Kyu(박인규)
Lee, Jin Gu(이진구)
Lee, Chang Young(이창영)
Chung, Kyung Young(정경영)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/107532
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