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The prognostic significance of multiple station N2 in patients with surgically resected stage IIIA N2 non-small cell lung cancer

 Jin Gu Lee  ;  Chang Young Lee  ;  In Kyu Park  ;  Dae Joon Kim  ;  Sang Ho Cho  ;  Kil Dong Kim  ;  Kyung Young Chung 
 Journal of Korean Medical Science, Vol.23(4) : 604-608, 2008 
Journal Title
 Journal of Korean Medical Science 
Issue Date
Adult ; Aged ; Carcinoma, Non-Small-Cell Lung/mortality* ; Carcinoma, Non-Small-Cell Lung/pathology ; Female ; Humans ; Lung Neoplasms/mortality* ; Lung Neoplasms/pathology ; Male ; Middle Aged ; Neoplasm Metastasis ; Neoplasm Staging ; Prognosis ; Survival Rate
Lung Neoplsms ; Lymph Node ; Neoplasm Metastasis ; Prognosis
Mediastinal (N2) lymph node involvement is heterogeneous with huge variation in the extent and grouped together under stage IIIA. However, they showed a different survival even in the same stage. We tried to determine the prognostic implication of the multiple station N2 lymph node metastasis in stage IIIA N2 non-small cell lung cancer (NSCLC). The survival of stage IIIA N2 was analyzed according to the number of N2 station and their survival was compared with that of stage IIIB. In stage IIIA N2 NSCLC, multivariate analysis indicated that multiple station N2 was one of the independent prognostic factors for poor survival. The 5-yr survival of multiple station N2 IIIA (20.4%) was lower than that of single station N2 IIIA (33.8%) significantly (p=0.016). but when it was compared with that of stage IIIB (15.5%), there was no difference. Therefore, we suggest that multiple station N2 should be considered similar to stage IIIB disease with regard to predicting survival and accordingly should receive a new position in the TNM staging system.
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1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dae Joon(김대준)
Park, In Kyu(박인규)
Lee, Jin Gu(이진구)
Lee, Chang Young(이창영)
Chung, Kyung Young(정경영)
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