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Deposits of transforming growth factor-beta-induced protein in granular corneal dystrophy type II after LASIK

 Tae-im Kim  ;  Mi In Roh  ;  Hans E. Grossniklaus  ;  Shin Jeong Kang  ;  Stephen M. Hamilton  ;  Daniel F. Schorderet  ;  W. Barry Lee  ;  Eung Kweon Kim 
 CORNEA, Vol.27(1) : 28-32, 2008 
Journal Title
Issue Date
Adult ; Azo Compounds ; Coloring Agents ; Congo Red ; Corneal Dystrophies, Hereditary/metabolism* ; Corneal Dystrophies, Hereditary/surgery ; Corneal Stroma/metabolism* ; Eosine Yellowish-(YS) ; Extracellular Matrix Proteins/metabolism* ; Humans ; Immunoenzyme Techniques ; Keratomileusis, Laser In Situ* ; Keratoplasty, Penetrating ; Male ; Methyl Green ; Middle Aged ; Staining and Labeling/methods ; Surgical Flaps* ; Transforming Growth Factor beta/metabolism*
granular corneal dystrophy type II ; hyaline ; antitransforming growth factor-b–induced protein ; laser in situ keratomileusis
PURPOSE: To analyze components of the deposits in the corneal flap interface of granular corneal dystrophy type II (GCD II) patients after laser in situ keratomileusis (LASIK). METHODS: Four corneal GCD II specimens displaying disease exacerbation after LASIK were analyzed. Three of these specimens included the recipient corneal button after penetrating keratoplasty or deep lamellar keratoplasty for advanced GCD II after LASIK. The fourth specimen, a similar case of GCD II after LASIK, included the amputated corneal flap. Specimens were processed for histopathologic and immunohistochemical analyses. RESULTS: Corneal stromal deposits in the LASIK flaps of all specimens were stained with 3 anti-transforming growth factor-beta-induced protein (TGFBIp) antibodies. The deposits displayed bright red color staining with Masson trichrome; however, negative staining was seen with Congo red, suggesting that hyaline is the main component localizing to the TGFBIp deposits rather than amyloid. CONCLUSIONS: Amorphous granular material deposited along the interface of the LASIK flap in GCD II corneas is composed mainly of hyaline deposits.
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1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Eung Kweon(김응권) ORCID logo https://orcid.org/0000-0002-1453-8042
Kim, Tae Im(김태임) ORCID logo https://orcid.org/0000-0001-6414-3842
Roh, Mi In(노미인)
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