2 302

Cited 10 times in

Prevalence and patterns of anti-nuclear antibodies in Korean children with juvenile idiopathic arthritis according to ILAR criteria

Authors
 JI Shin  ;  KH Kim  ;  JK Chun  ;  TJ Lee  ;  KJ Kim  ;  HS Kim  ;  DS Kim 
Citation
 SCANDINAVIAN JOURNAL OF RHEUMATOLOGY, Vol.37(5) : 348-351, 2008 
Journal Title
 SCANDINAVIAN JOURNAL OF RHEUMATOLOGY 
ISSN
 0300-9742 
Issue Date
2008
MeSH
Adolescent ; Antibodies, Antinuclear/blood* ; Arthritis, Juvenile/classification* ; Arthritis, Juvenile/diagnosis ; Arthritis, Juvenile/immunology* ; Biomarkers/blood ; Blood Sedimentation ; Child ; Child, Preschool ; Female ; Follow-Up Studies ; HLA-B27 Antigen/blood ; Humans ; Infant ; Korea ; Male ; Predictive Value of Tests ; Prevalence ; Severity of Illness Index ; Sex Characteristics
Keywords
Adolescent ; Antibodies, Antinuclear/blood* ; Arthritis, Juvenile/classification* ; Arthritis, Juvenile/diagnosis ; Arthritis, Juvenile/immunology* ; Biomarkers/blood ; Blood Sedimentation ; Child ; Child, Preschool ; Female ; Follow-Up Studies ; HLA-B27 Antigen/blood ; Humans ; Infant ; Korea ; Male ; Predictive Value of Tests ; Prevalence ; Severity of Illness Index ; Sex Characteristics
Abstract
OBJECTIVES: To investigate the prevalence and patterns of anti-nuclear antibodies (ANA) in different subtypes of juvenile idiopathic arthritis (JIA) according to the International League of Associations for Rheumatology (ILAR) criteria. METHODS: One hundred and fifty-three Korean patients (M:F 83:70) with JIA were followed between 1990 and 2006 and were tested for ANA by an indirect immunofluorescence method using HEp-2 cells as the substrate. ANA tests were repeated in 37 patients during the course of the disease. The median age at onset was 7.5 years (range 0.8-15.9 years). RESULTS: ANA were positive in 50 (33%) of the 153 patients at a dilution of 1:40 or higher (>1:40 in 70%, >1:80 in 2%, >1:160 in 16%, >1:320 in 2%, and >1:640 in 10%). The patterns of immunofluorescence staining were homogeneous in 50%, speckled in 38%, nucleolar in 8%, and centromere in 4%. ANA titres were decreased in 25 (68%) of the 37 patients, and the nuclear fluorescence patterns changed in 14 (38%) during follow-up. ANA seropositivity was associated with female sex (p<0.0001), negative HLA-B27 (p = 0.01), and a persistently elevated erythrocyte sedimentation rate (ESR) at follow-up (p = 0.014). Furthermore, a high ANA titre (>1:160) was associated with a poor clinical outcome (active patients at follow-up) (p = 0.005). CONCLUSIONS: ANA may be an important marker of disease activity in patients with JIA. ANA titres tend to decrease during disease remission but the fluorescence patterns do not appear to be related to disease activity or clinical outcome.
Full Text
http://informahealthcare.com/doi/abs/10.1080/03009740801998762
DOI
10.1080/03009740801998762
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ki Hwan(김기환)
Kim, Dong Soo(김동수)
Kim, Hyon Suk(김현숙) ORCID logo https://orcid.org/0000-0001-5662-7740
Shin, Jae Il(신재일) ORCID logo https://orcid.org/0000-0003-2326-1820
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/107380
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links