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급성 허혈성 뇌졸중치료 패러다임의 전환

Other Titles
 Breaking a Paradigm in Treatment of Acute Ischemic Stroke 
 신수정  ;  조경주  ;  김현우  ;  김경환 
 Journal of Neurocritical Care, Vol.1(1) : 1-11, 2008 
Journal Title
Journal of Neurocritical Care
Issue Date
Stroke ; MERCI ; Neurocritical care
Stroke is the second leading cause of death in Korea and responsible for serious long-term disability. Although rt-PA is an approved drug, only 1-3% of stroke patients are receiving the treatment because of its limited 3 hour time window. In this review, we will overview the basic molecular mechanism of acute ischemic stroke and current stroke treatment then discuss about current issue in Korea. Basic concept of stroke treatment is focused on saving the ischemic penumbra; area that is at risk of cell death but potentially salvageable. Apoptosis are believed to play critical roles in ischemic damage, especially in the penumbral zone. Apoptosis is an active form of cell death as a strategy to preserve genomic stability from DNA damage. If DNA damage is overwhelming the capacity of DNA repair, cells that harbor DNA damage are removed from the population by death. Execution of apoptosis is preceded rapidly by activation of complex signal pathways like caspase-dependent and caspase-independent pathways. By ‘turning off’ the death signal which is activated by massive DNA damage, initiation of apoptosis can be stopped and this concept can be a new therapeutic target of acute ischemic stroke. Reperfusion therapy and neuroprotective agent are two main streams for treatment of acute ischemic stroke. Although, many clinical trials have been done, rt-PA is the only FDA approved medical therapy for patients who can be treated within 3 hours of stroke onset. Emerging endovascular mechanical reperfusion device (clot retrieval device or MERCI) is approved by FDA and its results of recent clinical trials are promising. Neuroprotective agents were successful in animal models of ischemia, they have been unsuccessful in human trials. Clinical trials of NXY-059, one of promising neuroprotective agents, fail to widen the therapeutic window. So far, treatments of acute ischemic stroke have been based on epidemiological approach, not molecular pathophysiology. Introduction of neurocritical care, which will provide more professional, true meaning of treatment, is urgent. And paradigm of treatment of acute ischemic stroke should be focused on repairing damaged neuron by ischemia, not preventing further damage by reperfusion or neuroprotective agent
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kim, Gyung Whan(김경환) ORCID logo https://orcid.org/0000-0001-7053-4372
Kim, Hyun Woo(김현우)
Cho, Kyuong Joo(조경주)
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