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Combined effect of tumour necrosis factor-alpha and interleukin-13 polymorphisms on bronchial hyperresponsiveness in Korean children with asthma.

Authors
 H-B. Kim  ;  M-J. Kang  ;  S-Y. Lee  ;  H-S. Jin  ;  J-H. Kim  ;  B-S. Kim  ;  S-O. Jang  ;  Y-C. Lee  ;  M-H. Sohn  ;  K-E. Kim  ;  S-J. Hong 
Citation
 CLINICAL AND EXPERIMENTAL ALLERGY, Vol.38(5) : 774-780, 2008 
Journal Title
 CLINICAL AND EXPERIMENTAL ALLERGY 
ISSN
 0954-7894 
Issue Date
2008
MeSH
Alleles ; Asthma/genetics* ; Bronchial Hyperreactivity/genetics* ; Child ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; Humans ; Interleukin-13/genetics* ; Korea ; Male ; Polymorphism, Genetic* ; Tumor Necrosis Factor-alpha/genetics*
Keywords
asthma ; bronchial hyperresponsiveness ; combined effect ; IL‐13 ; TNF‐α
Abstract
BACKGROUND: TNF-alpha and IL-13, two pivotal pro-inflammatory cytokines, are increased in asthmatic airways and may be linked to asthma susceptibility and/or bronchial hyperresponsiveness (BHR). OBJECTIVE: We investigated the association between the TNF-alpha-308G/A polymorphism and asthma susceptibility or asthma-related phenotypes in Korean children with asthma, and tested for a combined effect with IL-13 polymorphisms. METHODS: Asthmatic children (n=719) and non-atopic healthy control children (n=243) were evaluated for asthma phenotypes including total serum IgE and BHR to methacholine. Genotypes were determined by PCR-restriction fragment length polymorphism analysis. RESULTS: The allele frequency of TNF-alpha-308A in asthmatics (14.1%) was higher than that in control children [8.7%, odds ratio (OR) 1.72, 95% confidence interval (CI) 1.05-2.82]. Significantly lower PC(20) values were found in asthmatic children carrying one or two copies of the TNF-alpha risk allele (-308A) vs. those homozygous for the common allele (P=0.026). Combined analysis revealed that atopic asthmatic children co-inherited the risk alleles of TNF-alpha-308G/A and IL-13 +2044G/A more frequently than control children (aOR 1.91, 95% CI 1.00-3.65), and asthmatic children co-inheriting both risk alleles had significantly lower PC(20) values vs. asthmatic children homozygous for the common alleles (P=0.024). CONCLUSION: The TNF-alpha promoter polymorphism (-308G/A) may be associated with asthma susceptibility and BHR in Korean children with asthma. In addition, there appears to be a synergistic effect between the TNF-alpha promoter polymorphism and an IL-13 coding region polymorphism in terms of asthma susceptibility and BHR in this population.
DOI
10.1111/j.1365-2222.2008.02965.x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyu Earn(김규언)
Sohn, Myung Hyun(손명현) ORCID logo https://orcid.org/0000-0002-2478-487X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/107274
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